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Table 4 Distribution of SERPINE2 genotypes according to the existence and severity of panlobular emphysematous changes

From: SERPINE2 haplotype as a risk factor for panlobular type of emphysema

Genotype

No radiologic changes#

N (%)

Radiologic changes*

N (%)

OR (95% CI)

Subnormal changes+

N (%)

OR (95% CI)

Pathologcal changes++

N (%)

OR (95% CI)

rs729631

       

G/G

500 (64.6)

85 (51.2)

1.0

60 (56.1)

1.0

25 (42.4)

1.0

G/C

245 (31.7)

70 (42.2)

1.66 (1.15-2.38)

42 (39.3)

1.43 (0.93-2.20)

28 (47.4)

2.19 (1.23-3.91)

C/C

29 (3.7)

11 (6.6)

2.22 (1.05-4.72)

5 (4.7)

1.43 (0.52-3.92)

6 (10.2)

4.37 (1.61-11.86)

  1. #Number of subjects with no emphysematous changes
  2. *Number of subjects with emphysema score positive
  3. Adjusted for age, sex, PYs, and years of asbestos exposure
  4. +Number of subjects with emphysema score less than one (less than two in emphysema sum score)
  5. ++Number of subjects with emphysema score one or higher (two or higher in emphysema sum score)
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BMC Medical Genetics

ISSN: 1471-2350

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