SERPINE2 haplotype as a risk factor for panlobular type of emphysema

BMC Medical Genetics

Table 2 Association between SERPINE2 polymorphisms, emphysema findings and pulmonary function

Phenotype	SNP	β^#	p-value
Emphysema score	rs729631	0.018	0.570
	rs840088	-0.016	0.614
Centrilobular	rs729631	0.000	0.987
	rs840088	0.008	0.794
Paraceptal	rs729631	-0.025	0.440
	rs840088	-0.015	0.637
Panlobular	rs729631	0.094	0.003*
	rs840088	-0.029	0.369
Bullae	rs729631	-0.010	0.767
	rs840088	-0.028	0.383
FEV₁	rs729631	-0.028	0.377
	rs840088	-0.002	0.942
FVC	rs729631	-0.044	0.182
	rs840088	0.025	0.441
FEV₁/FVC	rs729631	0.004	0.892
	rs840088	-0.047	0.124
DL_CO	rs729631	-0.032	0.310
	rs840088	0.014	0.648
DL_CO/VA	rs729631	-0.011	0.738
	rs840088	-0.026	0.401

DL_CO = Single breath diffusing capacity for carbon monoxide, % of predicted; DL_CO/VA = specific diffusing capacity, % of predicted; FEV₁ = Forced expiratory volume in 1 second, % of predicted; FVC = forced vital capacity, % of predicted; ^#Standardized coefficient β; *p < 0.05. Covariates included in analysis: Age, sex, PYs, years of asbestos exposure (emphysema and subtypes); PYs and years of asbestos exposure (FEV₁, FVC, DL_CO, and DL_CO/VA); age, sex, PYs, years of asbestos exposure, height (FEV₁/FVC).

ISSN: 1471-2350