Table 1 Summary of the nine GWAS included in the meta-analysis for 8q24.
Cancer | Ref | Study | Study size | Cases | Controls | Cancer subtypes | Study Notes |
|---|---|---|---|---|---|---|---|
Ovarian | UK | 4170 | 1817 | 2353 | Â | Majority of controls from UK 1958 birth cohort | |
Ovarian | [36] | US | 3715 | 1815 | 1900 | epithelial ovarian cancer | Four incident case-control studies: Mayo Clinic Ovarian Cancer Study, Duke University's North Carolina Ovarian Cancer Study, University of Toronto Familial Ovarian Tumor Study, H. Lee Moffitt Cancer Center and Research Institute's Tampa Bay Ovarian Cancer Study |
Glioma | [34] | Mayo Clinic | 350 | 176 | 174 | high-grade glioblastoma, anaplastic astrocytoma | Â |
Lung | [32] | Mayo Clinic | 754 | 377 | 377 | adenocarcinoma, other | Cases and controls were never smokers (i.e., had smoked fewer than 100 cigarettes in their lifetime) |
Lung | [27] | CGEMS/PLCO | 1629 | ~800 | ~800 | adenocarcinoma, squamous cell carcinoma, small-cell lung cancer, other | Cases and controls consisted of both smokers & non-smokers |
Prostate | [28] | CGEMS/PLCO | 2252 | 1151 | 1101 | aggressive, non-aggressive | Â |
Breast | CGEMS/Nurses' Health Study | 2287 | 1145 | 1142 | Â | Postmenopausal women with matching based on use of hormone replacement therapy | |
Pancreatic | [31] | CGEMS/PanScan | 7174 | 3532 | 3642 | primary adenocarcinoma of the exocrine pancreas | Consisted of 12 cohort and 8 case-control studies |
Colon | [33] | Colon Family Registry (CFR) | 2190 | ~1000 | ~1000 | invasive, microsatellite stable or low microsatellite instability colorectal cancer | Cases had no germline mismatch repair mutations |