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Table 4 The most statistically significant association (P ≤ 0.005) between single nucleotide polymorphisms and the LINE-1 methylation phenotype a, b, d, e, f

From: Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study

Gene rs# Nominal P Effectc Chr Coded allele Coded allele frequency Genetic Modelg Typeh
MTHFR rs12121543 4.29E-03 0.48 1 A 24% R I
  1. aModel adjusted for age, smoking, and residuals of plasma folate, plasma vitamin B-6, and plasma vitamin B-12; forward strand allele shown.
  2. bNo FDR-adjusted P values reached False Discovery Rate significance threshold of 0.05.
  3. cEffect represents per genotype change in LINE-1 element methylation standard deviation.
  4. dNo sparse data (fewer than 5 individuals per category) for any genotype categories of these SNPs.
  5. eNo SNPs map to more than one gene.
  6. fNo lower quality SNPs.
  7. gD:Dominant; R:Recessive; A:Additive; O:Overdominant.
  8. h5':5' region; 3':3' region; CN:Coding nonsynonymous; CS:Coding synonymous; I:Intronic.