Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study

Table 4 The most statistically significant association (P ≤ 0.005) between single nucleotide polymorphisms and the LINE-1 methylation phenotype ^{a, b, d, e, f}

Gene	rs#	Nominal P	Effect^c	Chr	Coded allele	Coded allele frequency	Genetic Model^g	Type^h
MTHFR	rs12121543	4.29E-03	0.48	1	A	24%	R	I

^aModel adjusted for age, smoking, and residuals of plasma folate, plasma vitamin B-6, and plasma vitamin B-12; forward strand allele shown.
^bNo FDR-adjusted P values reached False Discovery Rate significance threshold of 0.05.
^cEffect represents per genotype change in LINE-1 element methylation standard deviation.
^dNo sparse data (fewer than 5 individuals per category) for any genotype categories of these SNPs.
^eNo SNPs map to more than one gene.
^fNo lower quality SNPs.
^gD:Dominant; R:Recessive; A:Additive; O:Overdominant.
^h5':5' region; 3':3' region; CN:Coding nonsynonymous; CS:Coding synonymous; I:Intronic.

ISSN: 1471-2350