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Table 4 Meta-analysis of effects of rs9514089 on gallstone risk in the Sorbs, Aachen cohort and Stuttgart cohort

From: Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts

  Sorbs   Aachen   Stuttgart    
Trait p (rec) OR (rec) p (rec) OR (rec) p (rec) OR (rec) p meta OR meta
   [95% CI]   [95% CI]   [95% CI]   [95% CI]
gallstone (yes versus no) all 0.10 0.60 0.01 2.19 0.46 1.5 0.41 1.19
   [0.32;1.11]   [1.19;4.17]   [0.51;4.43]   [0.79; 1.78]
gallstone (yes versus no) BMI ≤ 26 0.09 0.30 0.04 2.59 0.11 4.0 0.24 1.54
   [0.07;1.21]   [1.02;7.01]   [0.67;23.95]   [0.75; 3.17]
gallstone (yes versus no) BMI > 26 0.29 0.72 0.12 1.88 0.65 0.72 0.99 0.99
   [0.36;1.47]   [0.80;4.62]   [0.18;2.96]   [0.60; 1.66]
gallstone (yes versus no) female 0.18 0.62 0.18 1.81 0.99 0.99 0.79 1.08
   [0.31;1.26]   [0.78;4.33]   [0.27;3.58]   [0.61; 1.90]
gallstone (yes versus no) male 0.34 0.53 0.03 2.79 0.37 2.5 0.22 1.59
   [0.15;1.95]   [1.07;7.92]   [0.32;19.54]   [0.76; 3.32]
  1. Meta-analysis of three independent cohorts (Sorbs - 183 cases/826 controls, Stuttgart - 56 cases/71 controls, Aachen - 184 cases/184). Analyses were performed under the recessive mode of inheritance in a fixed effects model. Results are presented as odds ratios (OR) and their 95% confidence intervals (95% CI). Effect directions were standardized to the minor allele.