| |
Sorbs
| |
Aachen
| |
Stuttgart
| | | |
|---|
|
Trait
|
p (rec)
|
OR (rec)
|
p (rec)
|
OR (rec)
|
p (rec)
|
OR (rec)
|
p meta
|
OR meta
|
|---|
| | |
[95% CI]
| |
[95% CI]
| |
[95% CI]
| |
[95% CI]
|
|---|
|
gallstone (yes versus no) all
|
0.10
|
0.60
|
0.01
|
2.19
|
0.46
|
1.5
|
0.41
|
1.19
|
| | |
[0.32;1.11]
| |
[1.19;4.17]
| |
[0.51;4.43]
| |
[0.79; 1.78]
|
|
gallstone (yes versus no) BMI ≤ 26
|
0.09
|
0.30
|
0.04
|
2.59
|
0.11
|
4.0
|
0.24
|
1.54
|
| | |
[0.07;1.21]
| |
[1.02;7.01]
| |
[0.67;23.95]
| |
[0.75; 3.17]
|
|
gallstone (yes versus no) BMI > 26
|
0.29
|
0.72
|
0.12
|
1.88
|
0.65
|
0.72
|
0.99
|
0.99
|
| | |
[0.36;1.47]
| |
[0.80;4.62]
| |
[0.18;2.96]
| |
[0.60; 1.66]
|
|
gallstone (yes versus no) female
|
0.18
|
0.62
|
0.18
|
1.81
|
0.99
|
0.99
|
0.79
|
1.08
|
| | |
[0.31;1.26]
| |
[0.78;4.33]
| |
[0.27;3.58]
| |
[0.61; 1.90]
|
|
gallstone (yes versus no) male
|
0.34
|
0.53
|
0.03
|
2.79
|
0.37
|
2.5
|
0.22
|
1.59
|
| | |
[0.15;1.95]
| |
[1.07;7.92]
| |
[0.32;19.54]
| |
[0.76; 3.32]
|
- Meta-analysis of three independent cohorts (Sorbs - 183 cases/826 controls, Stuttgart - 56 cases/71 controls, Aachen - 184 cases/184). Analyses were performed under the recessive mode of inheritance in a fixed effects model. Results are presented as odds ratios (OR) and their 95% confidence intervals (95% CI). Effect directions were standardized to the minor allele.
