Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts

Table 4 Meta-analysis of effects of rs9514089 on gallstone risk in the Sorbs, Aachen cohort and Stuttgart cohort

	Sorbs		Aachen		Stuttgart
Trait	p (rec)	OR (rec)	p (rec)	OR (rec)	p (rec)	OR (rec)	p meta	OR meta
		[95% CI]		[95% CI]		[95% CI]		[95% CI]
gallstone (yes versus no) all	0.10	0.60	*0.01*	2.19	0.46	1.5	0.41	1.19
		[0.32;1.11]		[1.19;4.17]		[0.51;4.43]		[0.79; 1.78]
gallstone (yes versus no) BMI ≤ 26	0.09	0.30	*0.04*	2.59	0.11	4.0	0.24	1.54
		[0.07;1.21]		[1.02;7.01]		[0.67;23.95]		[0.75; 3.17]
gallstone (yes versus no) BMI > 26	0.29	0.72	0.12	1.88	0.65	0.72	0.99	0.99
		[0.36;1.47]		[0.80;4.62]		[0.18;2.96]		[0.60; 1.66]
gallstone (yes versus no) female	0.18	0.62	0.18	1.81	0.99	0.99	0.79	1.08
		[0.31;1.26]		[0.78;4.33]		[0.27;3.58]		[0.61; 1.90]
gallstone (yes versus no) male	0.34	0.53	*0.03*	2.79	0.37	2.5	0.22	1.59
		[0.15;1.95]		[1.07;7.92]		[0.32;19.54]		[0.76; 3.32]

Meta-analysis of three independent cohorts (Sorbs - 183 cases/826 controls, Stuttgart - 56 cases/71 controls, Aachen - 184 cases/184). Analyses were performed under the recessive mode of inheritance in a fixed effects model. Results are presented as odds ratios (OR) and their 95% confidence intervals (95% CI). Effect directions were standardized to the minor allele.

ISSN: 1471-2350