Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts

Table 3 Association of rs9514089 with metabolic traits in the Sorbs

Trait	N	p (ADD Mode)	beta (ADD)	SE beta
total cholesterol [mmol/l]	907	0.17	0.011	0.008
HDL cholesterol [mmol/l]	907	0.78	0.003	0.010
LDL cholesterol [mmol/l]	907	0.10	0.021	0.013
Triglycerides [mmol/l]	907	0.41	0.018	0.022
Apolipoprotein-B [g/l]	905	0.17	0.015	0.011
fasting insulin [pmol/l]	886	0.42	-0.020	0.025
fasting glucose [mmol/l]	886	0.46	0.003	0.004
BMI [kg/m²]	1019	0.23	-0.009	0.007
fat mass [%]	1019	0.91	0.002	0.017

Association of rs9514089 with components of the metabolic syndrome. Analyses were performed in the additive (ADD) mode of inheritance by linear regression analyses. Age, gender and BMI were used as covariates (for BMI and fat mass only age and gender). Results are presented as betas and their standard errors (SE). Effect directions were standardized to the minor allele. For analyses of glucose and insulin only non-diabetic subjects were included, effects on lipid traits were only assessed in subjects without lipid-lowering medication.

ISSN: 1471-2350