Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts

Table 2 Association of rs9514089 with gallstones in the Sorbs

Trait	N	p (ADD Mode)	OR (ADD)	p (dom)	OR (dom)	p (rec)	OR (rec)
	(cases/controls)		[95% CI]		[95% CI]		[95% CI]
gallstone (yes versus no) all	183/826	0.19	0.83	0.47	0.87	0.10	0.60
			[0.63;1.09]		[0.61;1.26]		[0.32;1.11]
gallstone (yes versus no) BMI ≤ 26	49/435	*0.05*	0.57	0.14	0.58	0.09	0.30
			[0.33;1.01]		[0.29;1.19]		[0.07;1.21]
gallstone (yes versus no) BMI > 26	134/391	0.52	0.92	0.85	0.97	0.29	0.72
			[0.66;1.26]		[0.63;1.49]		[0.36;1.47]
gallstone (yes versus no) female	139/465	0.11	0.77	0.19	0.75	0.18	0.62
			[0.55;1.06]		[0.48;1.16]		[0.31:1.26]
gallstone (yes versus no) female and BMI ≤ 26	39/275	*0.05*	0.51	0.14	0.54	0.07	0.20
			[0.26;0.99]		[0.24;1.22]		[0.33;1.19]
gallstone (yes versus no) male	44/361	0.95	1.02	0.49	1.28	0.34	0.53
			[0.61;1.70]		[0.64;2.55]		[0.15;1.95]
gallstone (OP versus no) all	114/826	0.51	0.89	0.90	0.97	0.25	0.64
			[0.64;1.24]		[0.62;1.52]		[0.31;1.35]

Association of rs9514089 with gallstone risk. Analyses were performed in the additive (ADD), dominant (dom) and recessive (rec) mode of inheritance by logistic regression analyses. In the total cohort age, gender and BMI were used as covariates, in the stratified analyses/subgroup analyses only age and gender or BMI, respectively. Results are presented as odds ratios (OR) and their 95% confidence intervals (95% CI). Effect directions were standardized to the minor allele.

ISSN: 1471-2350