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Table 3 Top 20 independent* SNPs associated with renal sinus fat

From: Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study

SNP

Chr

Position

(Build 36)

Closest Gene

Effect

Allele

Effect

Allele

Frequency

Imputation

Score

P

β

(SE)

rs10744391

12

127890891

GLT1D1

A

0.29

0.67

1.2E-06

-0.224 (0.046)

rs580140

21

31739378

TIAM1

G

0.28

1.01

2.7E-06

-0.184

(0.039)

rs2282335

9

71055752

TJP2

A

0.36

0.98

3.6E-06

0.171

(0.037)

rs9375674

6

130258203

C6orf191

A

0.46

1.01

6.1E-06

0.158

(0.035)

rs1572050

13

93668766

GPC6

A

0.10

0.71

6.3E-06

-0.313 (0.069)

rs17736767

5

98607864

CHD1**

G

0.27

0.74

6.6E-06

-0.208 (0.046)

rs12785341

11

109901068

ARHGAP20

C

0.09

0.91

8.3E-06

0.290 (0.065)

rs6686423

1

155704134

FCRL5

A

0.31

0.76

8.4E-06

-0.194 (0.044)

rs7311875

12

127859220

SLC15A4

G

0.29

1.01

1.0E-05

-0.169 (0.038)

rs907849

11

72001536

PDE2A

G

0.23

0.91

1.2E-05

-0.190 (0.043)

rs2511864

11

82196824

PRCP

C

0.12

0.97

1.3E-05

0.238 (0.055)

rs332479

3

315440

CHL1

C

0.46

1.01

1.6E-05

-0.150 (0.035)

rs3815053

17

32076589

MRM1

C

0.48

1.01

1.6E-05

-0.151 (0.035)

rs4529412

7

49243390

VWC2**

T

0.19

0.98

2.1E-05

-0.192 (0.045)

rs1003136

5

127375714

SLC12A2**

A

0.36

0.97

2.1E-05

-0.154 (0.036)

rs6426644

1

20907695

KIF17

C

0.36

1.01

2.1E-05

-0.154

(0.036)

rs31093

16

53923677

IRX6

G

0.35

1.00

2.2E-05

-0.157

(0.037)

rs9516371

13

93688375

GPC6

T

0.33

0.98

2.2E-05

-0.158

(0.037)

rs7325697

13

98915794

TM9SF2

T

0.16

0.99

2.3E-05

0.203

(0.048)

rs1543400

20

38896007

MAFB**

C

0.50

0.97

2.6E-05

0.148

(0.035)

  1. β coefficients for the association for sex- and cohort-specific residuals of natural log-transformed renal sinus fat, adjusted for age and BMI.
  2. Nearby genes based on RefSeq genes (build 36). The gene is presented in boldface if the SNP is located within the gene.
  3. * Independent SNPs defined as those with r2 < 0.2 at any locus
  4. ** Closest reference gene > 60 Kb away