Genotype-phenotype correlations among BRCA14153delA and 5382insC mutation carriers from Latvia

BMC Medical Genetics

Table 4 Family histories of BRCA1 c.4034delA and c.5266dupC mutations carriers

Types of family histories	c.4034delA	c.5266dupC	95% CI	P-value
No data about cancer cases among 1^st and 2^nd degree relatives	9% (7)	22%(28)	2.44-23.56	0.02
At least 3 cancer cases among 1^st and 2^nd degree relatives (including breast and ovarian)	48% (38)	29% (37)	4.46-33.54	0.008
At least 3 cancer cases among 1^st and 2^nd degree relatives (without breast and ovarian)	14% (11)	6% (8)	-2.05-17.45	0.08
At least 4 cancer cases among 1^st and 2^nd degree relatives (including breast and ovarian)	30% (24)	15% (19)	2.14-27.86	0.01
Breast cancer families¹	9% (7)	24% (31)	4.25-25.75	0.01
Breast and ovarian cancer families²	34% (27)	18% (23)	2.61-29.39	0.01
Total amount of families included	79	128

¹ - Breast cancer families - all families with at least two 1^st or 2^nd (related through a man) degree relatives having breast cancer but without ovarian cancer cases in family.
² - Breast and ovarian cancer families - all families with at least two 1^st or 2^nd (related through a man) degree relatives having breast or ovarian cancers.

ISSN: 1471-2350