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Table 4 Family histories of BRCA1 c.4034delA and c.5266dupC mutations carriers

From: Genotype-phenotype correlations among BRCA14153delA and 5382insC mutation carriers from Latvia

Types of family histories c.4034delA c.5266dupC 95% CI P-value
No data about cancer cases among 1st and 2nd degree relatives 9% (7) 22%(28) 2.44-23.56 0.02
At least 3 cancer cases among 1st and 2nd degree relatives (including breast and ovarian) 48% (38) 29% (37) 4.46-33.54 0.008
At least 3 cancer cases among 1st and 2nd degree relatives (without breast and ovarian) 14% (11) 6% (8) -2.05-17.45 0.08
At least 4 cancer cases among 1st and 2nd degree relatives (including breast and ovarian) 30% (24) 15% (19) 2.14-27.86 0.01
Breast cancer families1 9% (7) 24% (31) 4.25-25.75 0.01
Breast and ovarian cancer families2 34% (27) 18% (23) 2.61-29.39 0.01
Total amount of families included 79 128   
  1. 1 - Breast cancer families - all families with at least two 1st or 2nd (related through a man) degree relatives having breast cancer but without ovarian cancer cases in family.
  2. 2 - Breast and ovarian cancer families - all families with at least two 1st or 2nd (related through a man) degree relatives having breast or ovarian cancers.