Table 1 Summary of gene/locus features identified through GWAS in selected previous studies for CVD related phenotypes
CVD related phenotype | Region | Reported gene(s) | Strongest SNP-risk allele from study | Risk allele frequency | P-value | Effect size | Reference |
|---|---|---|---|---|---|---|---|
Coronary heart disease | 10p11.23 | KIAA1462 | rs3739998-C | 0.44 | 1 × 10-11 | 1.15*[1.11-1.20] | [42] |
Heart Failure | 15q22.31 | USP3 | rs10519210 | 0.03 | 1 × 10-8 | 1.53*[1.05-2.24] | [43] |
Mortality with heart failure | 3p22.2 | CMTM7 | rs12638540-G | 0.043 | 3 × 10-7 | 1.53*[1.01-2.31] | [44] |
Coronary heart disease | 3q22.3 | MRAS | rs9818870-T | 0.15 | 7 × 10-13 | 1.15 *[1.11-1.19] | [42] |
Coronary heart disease | 6q25.3 | SLC22A3, LPAL2, LPA | 4-SNP haplotype-2 | 0.02 | 4 × 10-15 | 1.82*[1.57-2.12] | [45] |
Coronary heart disease | 9p21.3 | Intergenic | rs1333049-C | 0.47 | 3 × 10-19 | 1.36* [1.27-1.46] | [46] |
Coronary heart disease | 9p21.3 | CDKN2A, CDKN2B | rs1333049-C | 0.47 | 1 × 10-13 | 1.47* [1.27-1.70] | [7] |