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Table 1 Summary of gene/locus features identified through GWAS in selected previous studies for CVD related phenotypes

From: Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk

CVD related phenotype Region Reported gene(s) Strongest SNP-risk allele from study Risk allele frequency P-value Effect size Reference
Coronary heart disease 10p11.23 KIAA1462 rs3739998-C 0.44 1 × 10-11 1.15*[1.11-1.20] [42]
Heart Failure 15q22.31 USP3 rs10519210 0.03 1 × 10-8 1.53*[1.05-2.24] [43]
Mortality with heart failure 3p22.2 CMTM7 rs12638540-G 0.043 3 × 10-7 1.53*[1.01-2.31] [44]
Coronary heart disease 3q22.3 MRAS rs9818870-T 0.15 7 × 10-13 1.15 *[1.11-1.19] [42]
Coronary heart disease 6q25.3 SLC22A3, LPAL2, LPA 4-SNP haplotype-2 0.02 4 × 10-15 1.82*[1.57-2.12] [45]
Coronary heart disease 9p21.3 Intergenic rs1333049-C 0.47 3 × 10-19 1.36* [1.27-1.46] [46]
Coronary heart disease 9p21.3 CDKN2A, CDKN2B rs1333049-C 0.47 1 × 10-13 1.47* [1.27-1.70] [7]
  1. The genetic effect refers to the OR and [95% CI]. All listed values are from [6]