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Table 5 Association between severe dyspeptic symptoms and HTR3A c.-42C > T genotype stratified by 5-HTTLPR genotype in females and males

From: Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia

Gender

5-HTTLPR

Severe dyspeptic symptoms

HTR3Ac.-42C>T

OR (95% CI)

P value

   

CC

CT + TT

  

Female

LL

Yes

16 (45.7)

19 (54.3)

3.50 (1.37-8.90)

0.009

  

No

45 (75.0)

15 (25.0)

  
 

LS + SS

Yes

40 (51.3)

38 (48.7)

 

0.090

  

No

92 (61.7)

57 (38.3)

1.70 (0.93-3.14)

 

Male

LL

Yes

15 (62.5)

9 (37.5)

0.96 (0.32-2.89)

0.94

  

No

32 (63.0)

19 (37.0)

  
 

LS + SS

Yes

37 (62.0)

23 (38.0)

 

0.66

  

No

85 (63.0)

50 (37.0)

1.16 (0.59-2.28)

 
  1. Genotype distributions are depicted as number (%).
  2. *adjusted for age, IBS status, psycho neuroticism, use of anti depressive and acid suppressive medication and active coping style