Table 4 Association between severe dyspeptic symptoms and HTR3A c.-42C > T genotype stratified by gender and 5-HTTLPR genotype
From: Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia
| Â | Severe dyspeptic symptoms | HTR3A c.-42C>T | OR (95% CI) * | P value | |
|---|---|---|---|---|---|
| Â | Â | CC | CT + TT | Â | Â |
Gender | Â | Â | Â | Â | Â |
   Female | Yes | 56 (49.6) | 57 (50.4) | 2.05 (1.25-3.39) | 0.005 |
| Â | No | 137 (65.6) | 72 (34.4) | Â | Â |
   Male | Yes | 52 (61.9) | 32 (38.1) |  | 0.86 |
| Â | No | 117 (62.9) | 69 (37.1) | 1.05 (0.60-1.84) | Â |
5-HTTLPR | Â | Â | Â | Â | Â |
   LL | Yes | 31 (52.5) | 28 (47.5) | 2.00 (1.01-3.94) | 0.046 |
| Â | No | 77 (69.4) | 34 (30.6) | Â | Â |
   LS + SS | Yes | 77 (55.8) | 61 (44.2) |  | 0.15 |
| Â | No | 177 (62.3) | 107 (37.7) | 1.38 (0.88-2.15) | Â |