Table 3 Association of HTR3A c.-42C > T and 5-HTTLPR genotypes with dyspeptic symptom severity
From: Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia
Polymorphism | Genotype | Total N = 592 | Severe dyspeptic symptoms | OR (95% CI) * | P value | |
|---|---|---|---|---|---|---|
| Â | Â | Â | Yes N = 197 | No N = 395 | Â | Â |
HTR3A c.-42C>T | CC | 362 (61.1) | 108 (54.8) | 254 (64.3) | 1.00 | 0.027 |
| Â | CT | 200 (33.8) | Â | Â | Â | Â |
| Â | TT | 30 (5.1) | Â | Â | Â | Â |
| Â | CT + TT | 230 (38.9) | 89 (45.2) | 141 (35.7) | 1.50 (1.06-2.20) | Â |
5-HTTLPR | LL | 170 (28.7) | 59 (29.9) | 111 (28.1) | 1.00 | 0.60 |
| Â | LS | 310 (52.4) | Â | Â | Â | Â |
| Â | SS | 112 (18.9) | Â | Â | Â | Â |
| Â | LS + SS | 422 (71.2) | 138 (70.1) | 284 (71.9) | 0.90 (0.60-1.40) | Â |