TY - JOUR AU - Mujakovic, Suhreta AU - ter Linde, José JM AU - de Wit, Niek J. AU - van Marrewijk, Corine J. AU - Fransen, Gerdine AJ AU - Onland-Moret, N. Charlotte AU - Laheij, Robert JF AU - Muris, Jean WM AU - Grobbee, Diederick E. AU - Samsom, Melvin AU - Jansen, Jan BMJ AU - Knottnerus, André AU - Numans, Mattijs E. PY - 2011 DA - 2011/10/20 TI - Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia JO - BMC Medical Genetics SP - 140 VL - 12 IS - 1 AB - The association between anxiety and depression related traits and dyspepsia may reflect a common genetic predisposition. Furthermore, genetic factors may contribute to the risk of having increased visceral sensitivity, which has been implicated in dyspeptic symptom generation. Serotonin (5-HT) modulates visceral sensitivity by its action on 5-HT3 receptors. Interestingly, a functional polymorphism in HTR3A, encoding the 5-HT3 receptor A subunit, has been reported to be associated with depression and anxiety related traits. A functional polymorphism in the serotonin transporter (5-HTT), which terminates serotonergic signalling, was also found associated with these psychiatric comorbidities and increased visceral sensitivity in irritable bowel syndrome, which coexistence is associated with higher dyspeptic symptom severity. We investigated the association between these functional polymorphisms and dyspeptic symptom severity. SN - 1471-2350 UR - https://doi.org/10.1186/1471-2350-12-140 DO - 10.1186/1471-2350-12-140 ID - Mujakovic2011 ER -