Analysis of positional candidate genes in the AAA1 susceptibility locus for abdominal aortic aneurysms on chromosome 19

Table 5 Sequence changes detected by CD22 exon sequencing

	Chr. Pos. (Build 37)	Gene Feature	Allele Change	SNP Identifier	MAF (Caucasian)	mRNA Position	Amino Acid	Residue Change
1	35,823,999	Intron 3	C- > T	rs881456	0.021 (0.000)
2	35,824,019	Intron 3	C- > G	rs10419538	0.104 (0.181)
3	35,829,381	Intron 6	A- > G	rs7248108	0.042 (0.042)
4	35,831,986	Exon 7	C- > T	rs25677	0.042 (0.000)	1529	484	C- > C
5	35,832,381	Exon 8	G- > A		0.021	1721	548	R- > K
6	35,832,886	Intron 9	T- > A		0.021
7	35,835,940	Intron 10	C- > T	rs45453699	0.313
8	35,836,512	Exon 12	A- > G		0.021	2293	739	R- > G
9	35,836,530	Exon 12	G- > A	rs10406069	0.104 (0.292)	2311	745	G- > D
10	35,836,600	Exon 12	C- > A	rs34826052	0.042	2381	768	P- > P
11	35,837,148	Intron 13	G- > A	hCV25603572	0.021 (0.05)
12	35,837,150	Intron 13	C- > T		0.021
13	35,837,327	Intron 13	C- > T	rs58156121	0.063
14	35,837,428	Intron 13	G- > A	rs12985354	0.208 (0.383)
15	35,837,694	3'-UTR	C- > T	rs73031792	0.250	2715
16	35,837,705	3'-UTR	A- > G	rs35529786	0.167	2726
17	35,837,724-5	3'-UTR	GC I/D¹	rs34472317	0.042	2745-6
18	35,837,813	3'-UTR	C- > T		0.042	2834
19	35,837,846	3'-UTR	C- > T	rs16970255	0.042 (0.000)	2867
20	35,838,076	3'-UTR	C- > T	rs3088063	0.042 (0.055)	3097

¹Variant allele is GC insertion.
For definitions, see footnote to Table 4.
For details, see Additional file 11, Table S9 and Additional file 12, Table S10.

ISSN: 1471-2350