Assessment of heterogeneity between European Populations: a Baltic and Danish replication case-control study of SNPs from a recent European ulcerative colitis genome wide association study

Table 3 Odds ratios (OR) for the combined UC panels and heterogeneity test for the Northern countries (Baltic, Norwegian, and Danish) versus rest of Europe (German, British, Belgian, and Greek).

		Baltic, Norwegian, and Danish¹ 1275 cases and 2234 controls					German, British, Belgian, and Greek¹ 1822 cases and 3989 controls				Northern vs rest of Europe	Baltic, Norwegian, Danish, German, British, Belgian, and Greek 3097 cases/6223 controls
SNP	A1	P_BD	OR_CMH	95%CI	P_CMH	Power	P_BD	OR_CMH	95%CI	P_CMH	P_BD	OR_CMH	95%CI	P_CMH
rs7520292	A	0.98	1.02	0.89-1.16	0.75	43%	0.13	1.19	1.08-1.32	0.004	0.001	1.13	1.04-1.22	0.003
rs1488266 BTLA	C	0.98	0.92	0.77-1.09	0.35	49%	0.50	0.83	0.72-0.95	0.01	0.14	0.87	0.78-0.97	0.01
rs3103190	G	0.54	0.93	0.84-1.03	0.20	30%	0.06	0.86	0.79-0.94	0.001	0.71	0.89	0.84-0.96	0.001
rs12518307	A	0.34	1.07	0.96-1.20	0.18	39%	0.17	0.86	0.78-0.95	0.002	0.007	0.95	0.88-1.02	0.16
rs2395609 TCP11	G	0.59	0.98	0.88-1.09	0.73	39%	0.17	0.84	0.77-0.92	0.0002	0.01	0.90	0.84-0.96	0.002
rs7809799 SMURF1/KPNA71	G	0.09	1.20	0.95-1.52	0.10	94%	0.81	1.43	1.19-1.71	0.0001	0.10	1.34	1.16-1.55	0.00005
rs6966125 TNP03	G	0.45	1.01	0.88-1.16	0.82	54%	0.34	0.83	0.73-0.93	0.001	0.12	0.90	0.83-0.99	0.02
rs638300	T	0.65	1.03	0.91-1.18	0.55	55%	0.10	1.19	1.08-1.31	0.0003	0.18	1.14	1.05-1.23	0.001
rs6119625 FER1L4	G	0.72	1.12	0.97-1.29	0.11	47%	0.90	1.19	1.06-1.33	0.001	0.29	1.17	1.07-1.28	0.0006
rs6125345	C	0.33	1.03	0.90-1.18	0.64	39%	0.45	1.15	1.03-1.27	0.006	0.29	1.11	1.02-1.20	0.01
rs5771069 IL17REL	A	0.06	0.89	0.79-0.98	0.02	29%	0.54	0.89	0.82-0.97	0.008	0.86	0.89	0.84-0.95	0.0005

¹Data on the 11 SNPs in the Norwegian, German, British, Belgian, and Greek cohort, and on rs5771069 and rs7809799 in the Baltic cohort is derived from the study of Franke et al [7]. In the study by Franke et al [7] the rs5771069 G allele is denoted as the A1 allele, whereas in this study the rs5771069 A allele is denoted as the A1 allele. Combined P-values (P_CMH) and combined ORs (OR_CMH) of the Cochran-Mantel-Haenszel (CMH) test statistic; Breslow-Day test for odds ratio heterogeneity between countries (P_BD); A1: minor allele in healthy controls; F: allele frequency of A1 for cases (F_CA) and controls (F_CO), respectively; 95%CI: 95% confidence interval; nominal significant P-values are highlighted by bold type;

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