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Table 4 Change in ADAS-Cog scores among APOE4(+) participants

From: Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study

Day 45 Change from Baseline

      

gene

SNP

Allele

AC1202

n

Placebo

n

p-value

Difference(CI)

IDE

IDE-

IDE c/c (-)

0.119

28

1.536

23

0.276

1.417(-1.163, 3.998)

IDE

IDE+

IDE c/c (+)

4.083

4

-0.944

6

0.094

5.028(-0.892, 10.947)

IDE

rs2251101

C

4.083

4

-0.944

6

0.091

5.028(-0.827, 10.883)

IDE

rs2251101

Het

-0.091

11

2.909

11

0.126

3.000(-0.868, 6.868)

IDE

rs2251101

T

0.255

17

0.278

12

0.989

0.023(-3.397, 3.443)

IL1B

rs1143627

C

2.000

2

1.556

6

0.908

0.444(-7.234, 8.123)

IL1B

rs1143627

Het

-0.604

16

-0.400

10

0.914

0.204(-3.587, 3.995)

IL1B

rs1143627

T

1.436

13

2.061

11

0.746

0.625(-3.228, 4.477)

IL1B

rs16944

C

1.436

13

2.061

11

0.746

0.625(-3.228, 4.477)

IL1B

rs16944

Het

-0.604

16

-0.400

10

0.914

0.204(-3.587, 3.995)

IL1B

rs16944

T

2.000

2

1.556

6

0.908

0.444(-7.234, 8.123)

Day 90 Change from Baseline

      

IDE

IDE-

IDE c/c (-)

0.063

21

1.159

21

0.508

1.095(-2.211, 4.402)

IDE

IDE+

IDE c/c (+)

4.333

3

-1.278

6

0.143

5.611(-1.965, 13.187)

IDE

rs2251101

C

4.333

3

-1.278

6

0.143

5.611(-1.961, 13.183)

IDE

rs2251101

Het

0.333

8

2.933

10

0.308

2.600(-2.479, 7.679)

IDE

rs2251101

T

-0.103

13

-0.455

11

0.872

0.352(-4.035, 4.739)

IL1B

rs1143627

C

-1.333

1

1.111

6

0.687

2.444(-9.715, 14.603)

IL1B

rs1143627

Het

-0.152

11

0.185

9

0.894

0.337(-4.723, 5.396)

IL1B

rs1143627

T

0.758

11

1.033

10

0.910

0.276(-4.643, 5.194)

IL1B

rs16944

C

0.758

11

1.033

10

0.910

0.276(-4.643, 5.194)

IL1B

rs16944

Het

-0.152

11

0.185

9

0.894

0.337(-4.723, 5.396)

IL1B

rs16944

T

-1.333

1

1.111

6

0.687

2.444(-9.715, 14.603)

Day 104 Change from Baseline

      

IDE

IDE-

IDE c/c (-)

0.069

29

-0.476

21

0.733

0.545(-2.646, 3.737)

IDE

IDE+

IDE c/c (+)

2.333

3

1.667

6

0.866

0.667(-7.210, 8.543)

IDE

rs2251101

C

2.333

3

1.667

6

0.868

0.667(-7.357, 8.690)

IDE

rs2251101

Het

-0.267

10

-0.233

10

0.990

0.033(-5.041, 5.108)

IDE

rs2251101

T

0.246

19

-0.697

11

0.662

0.943(-3.356, 5.242)

IL1B

rs1143627

C

0.111

3

0.778

6

0.871

0.667(-7.534, 8.868)

IL1B

rs1143627

Het

-0.889

15

-0.292

8

0.814

0.597(-4.480, 5.675)

IL1B

rs1143627

T

1.692

13

-0.182

11

0.432

1.874(-2.877, 6.625)

IL1B

rs16944

C

1.692

13

-0.182

11

0.432

1.874(-2.877, 6.625)

IL1B

rs16944

Het

-0.889

15

-0.292

8

0.814

0.597(-4.480, 5.675)

IL1B

rs16944

T

0.111

3

0.778

6

0.871

0.667(-7.534, 8.868)