Day 45 Change from Baseline | Â | Â | Â | Â | Â | Â | ||
---|---|---|---|---|---|---|---|---|
gene | SNP | Allele | AC1202 | n | Placebo | n | p-value | Difference(CI) |
IDE | IDE- | IDE c/c (-) | 0.119 | 28 | 1.536 | 23 | 0.276 | 1.417(-1.163, 3.998) |
IDE | IDE+ | IDE c/c (+) | 4.083 | 4 | -0.944 | 6 | 0.094 | 5.028(-0.892, 10.947) |
IDE | rs2251101 | C | 4.083 | 4 | -0.944 | 6 | 0.091 | 5.028(-0.827, 10.883) |
IDE | rs2251101 | Het | -0.091 | 11 | 2.909 | 11 | 0.126 | 3.000(-0.868, 6.868) |
IDE | rs2251101 | T | 0.255 | 17 | 0.278 | 12 | 0.989 | 0.023(-3.397, 3.443) |
IL1B | rs1143627 | C | 2.000 | 2 | 1.556 | 6 | 0.908 | 0.444(-7.234, 8.123) |
IL1B | rs1143627 | Het | -0.604 | 16 | -0.400 | 10 | 0.914 | 0.204(-3.587, 3.995) |
IL1B | rs1143627 | T | 1.436 | 13 | 2.061 | 11 | 0.746 | 0.625(-3.228, 4.477) |
IL1B | rs16944 | C | 1.436 | 13 | 2.061 | 11 | 0.746 | 0.625(-3.228, 4.477) |
IL1B | rs16944 | Het | -0.604 | 16 | -0.400 | 10 | 0.914 | 0.204(-3.587, 3.995) |
IL1B | rs16944 | T | 2.000 | 2 | 1.556 | 6 | 0.908 | 0.444(-7.234, 8.123) |
Day 90 Change from Baseline | Â | Â | Â | Â | Â | Â | ||
IDE | IDE- | IDE c/c (-) | 0.063 | 21 | 1.159 | 21 | 0.508 | 1.095(-2.211, 4.402) |
IDE | IDE+ | IDE c/c (+) | 4.333 | 3 | -1.278 | 6 | 0.143 | 5.611(-1.965, 13.187) |
IDE | rs2251101 | C | 4.333 | 3 | -1.278 | 6 | 0.143 | 5.611(-1.961, 13.183) |
IDE | rs2251101 | Het | 0.333 | 8 | 2.933 | 10 | 0.308 | 2.600(-2.479, 7.679) |
IDE | rs2251101 | T | -0.103 | 13 | -0.455 | 11 | 0.872 | 0.352(-4.035, 4.739) |
IL1B | rs1143627 | C | -1.333 | 1 | 1.111 | 6 | 0.687 | 2.444(-9.715, 14.603) |
IL1B | rs1143627 | Het | -0.152 | 11 | 0.185 | 9 | 0.894 | 0.337(-4.723, 5.396) |
IL1B | rs1143627 | T | 0.758 | 11 | 1.033 | 10 | 0.910 | 0.276(-4.643, 5.194) |
IL1B | rs16944 | C | 0.758 | 11 | 1.033 | 10 | 0.910 | 0.276(-4.643, 5.194) |
IL1B | rs16944 | Het | -0.152 | 11 | 0.185 | 9 | 0.894 | 0.337(-4.723, 5.396) |
IL1B | rs16944 | T | -1.333 | 1 | 1.111 | 6 | 0.687 | 2.444(-9.715, 14.603) |
Day 104 Change from Baseline | Â | Â | Â | Â | Â | Â | ||
IDE | IDE- | IDE c/c (-) | 0.069 | 29 | -0.476 | 21 | 0.733 | 0.545(-2.646, 3.737) |
IDE | IDE+ | IDE c/c (+) | 2.333 | 3 | 1.667 | 6 | 0.866 | 0.667(-7.210, 8.543) |
IDE | rs2251101 | C | 2.333 | 3 | 1.667 | 6 | 0.868 | 0.667(-7.357, 8.690) |
IDE | rs2251101 | Het | -0.267 | 10 | -0.233 | 10 | 0.990 | 0.033(-5.041, 5.108) |
IDE | rs2251101 | T | 0.246 | 19 | -0.697 | 11 | 0.662 | 0.943(-3.356, 5.242) |
IL1B | rs1143627 | C | 0.111 | 3 | 0.778 | 6 | 0.871 | 0.667(-7.534, 8.868) |
IL1B | rs1143627 | Het | -0.889 | 15 | -0.292 | 8 | 0.814 | 0.597(-4.480, 5.675) |
IL1B | rs1143627 | T | 1.692 | 13 | -0.182 | 11 | 0.432 | 1.874(-2.877, 6.625) |
IL1B | rs16944 | C | 1.692 | 13 | -0.182 | 11 | 0.432 | 1.874(-2.877, 6.625) |
IL1B | rs16944 | Het | -0.889 | 15 | -0.292 | 8 | 0.814 | 0.597(-4.480, 5.675) |
IL1B | rs16944 | T | 0.111 | 3 | 0.778 | 6 | 0.871 | 0.667(-7.534, 8.868) |