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Table 3 Change in ADAS-Cog scores among APOE 4(-) participants

From: Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study

Day 45 Change from Baseline

      

gene

SNP

Allele

AC1202

n

Placebo

n

p-value*

Difference(CI)

IDE

IDE-

IDE c/c (-)

-2.772

19

2.071

23

0.000

4.843(2.568, 7.118)

IDE

IDE+

IDE c/c (+)

0.667

4

-0.667

1

0.745

1.333(-6.870, 9.536)

IDE

rs2251101

C

0.667

4

-0.667

1

0.744

1.333(-6.867, 9.534)

IDE

rs2251101

Het

-4.500

6

1.775

12

0.001

6.275(2.608, 9.942)

IDE

rs2251101

T

-1.974

13

2.394

11

0.005

4.368(1.364, 7.373)

IL1B

rs1143627

C

0.333

3

4.333

3

0.192

4.000(-2.103, 10.103)

IL1B

rs1143627

Het

-2.083

8

0.524

7

0.180

2.607(-1.261, 6.476)

IL1B

rs1143627

T

-3.633

10

1.997

13

0.001

5.631(2.487, 8.775)

IL1B

rs16944

C

-3.633

10

1.997

13

0.001

5.631(2.487, 8.775)

IL1B

rs16944

Het

-2.083

8

0.524

7

0.180

2.607(-1.261, 6.476)

IL1B

rs16944

T

0.333

3

4.333

3

0.192

4.000(-2.103, 10.103)

Day 90 Change from Baseline

      

IDE

IDE-

IDE c/c (-)

-3.729

16

2.156

19

0.003

5.885(2.192, 9.578)

IDE

IDE+

IDE c/c (+)

3.583

4

-5.333

1

0.146

8.917(-3.252, 21.086)

IDE

rs2251101

C

3.583

4

-5.333

1

0.132

8.917(-2.834, 20.667)

IDE

rs2251101

Het

-7.733

5

2.956

9

0.001

10.689(4.827, 16.551)

IDE

rs2251101

T

-1.909

11

1.437

10

0.148

3.346(-1.246, 7.938)

IL1B

rs1143627

C

-1.000

3

3.222

3

0.370

4.222(-5.241, 13.685)

IL1B

rs1143627

Het

-0.250

8

-0.389

6

0.964

0.139(-6.120, 6.398)

IL1B

rs1143627

T

-5.667

8

2.463

10

0.005

8.130(2.633, 13.627)

IL1B

rs16944

C

-5.667

8

2.463

10

0.005

8.130(2.633, 13.627)

IL1B

rs16944

Het

-0.250

8

-0.389

6

0.964

0.139(-6.120, 6.398)

IL1B

rs16944

T

-1.000

3

3.222

3

0.370

4.222(-5.241, 13.685)

Day 104 Change from Baseline

      

IDE

IDE-

IDE c/c (-)

-1.909

22

1.686

21

0.026

3.595(0.451, 6.739)

IDE

IDE+

IDE c/c (+)

4.833

4

-3.333

1

0.160

8.167(-3.356, 19.690)

IDE

rs2251101

C

4.833

4

-3.333

1

0.152

8.167(-3.117, 19.451)

IDE

rs2251101

Het

-4.546

8

0.867

10

0.028

5.413(0.625, 10.200)

IDE

rs2251101

T

-0.402

14

2.430

11

0.167

2.833(-1.234, 6.899)

IL1B

rs1143627

C

1.444

3

-0.333

3

0.670

1.778(-6.598, 10.153)

IL1B

rs1143627

Het

0.478

9

1.611

6

0.674

1.133(-4.273, 6.540)

IL1B

rs1143627

T

-3.333

12

0.894

12

0.048

4.228(0.040, 8.415)

IL1B

rs16944

C

-3.333

12

0.894

12

0.048

4.228(0.040, 8.415)

IL1B

rs16944

Het

0.478

9

1.611

6

0.674

1.133(-4.273, 6.540)

IL1B

rs16944

T

1.444

3

-0.333

3

0.670

1.778(-6.598, 10.153)

  1. *p-value < 0.05 bold, < 0.01 bold and underlined.