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Table 1 Allelic and genotypic frequencies for the SLCO1B1 polymorphisms according to ethnic groups

From: SLCO1B1 rs4149056 polymorphism associated with statin-induced myopathy is differently distributed according to ethnicity in the Brazilian general population: Amerindians as a high risk ethnic group

Nucleotide Change and Genotype

African descent

Mulatto

Caucasian descent

Amerindian

p value

n (100%)

97

332

603

182

 

SLCO1B1 rs4149056

     

TT

86 (88.7%)

241 (72.6%)

449 (74.5%)

97 (53.3%)

< 0.001

TC

11 (11.3%)

83 (25.0%)

129 (21.4%)

67 (36.8%)

 

CC

0

8 (2.4%)

25 (4.1%)

18 (9.9%)

 

C allele

5.7%

14.9%

14.8%

28.3%

< 0.001

SLCO1B1 rs4363657

     

TT

76 (78.4%)

216 (65.1%)

433 (71.8%)

99 (54.4%)

< 0.001

TC

21 (21.6%)

111 (33.4%)

154 (25.5%)

71 (39.0%)

 

CC

0

5 (1.5%)

16 (2.7%)

12 (6.6%)

 

C allele

10.8%

18.2%

15.4%

26.1%

< 0.001

  1. SLCO1B1 rs4149056: c.T521C, p.V174A (exon 5); SLCO1B1 rs4363657: g.T89595C (intron 11).
  2. Mulatto group was composed of mixed ethnicity subjects.
  3. p values were calculated using Chi-square test.