Table 5 Haplotype frequency of the LTA and TNFA genes SNPs in COPD patients vs. Healthy control individuals
Haplotypes* | Total freq. | Healthy controls n = 432 | COPD cases n = 199 | ORadj (95%CI)ª | p-value | |
|---|---|---|---|---|---|---|
1 | A A T C C C G G G G | 0.2827 | 0.2806 | 0.2982 | 1.00 | |
2 | C A C C A C G G G G | 0.1703 | 0.1815 | 0.1461 | 0.70 (0.45 - 1.08) | 0.11 |
3 | C G T A C C G A G G | 0.1311 | 0.1328 | 0.1220 | 1.03 (0.64 - 1.66) | 0.90 |
4 | C G T A C C G G G G | 0.1268 | 0.1280 | 0.1257 | 1.09 (0.67 - 1.78) | 0.72 |
5 | C A C C C C G G G G | 0.0806 | 0.0723 | 0.0944 | 1.27 (0.72 - 2.23) | 0.40 |
6 | A A T C C T G G G A | 0.0762 | 0.0749 | 0.0781 | 1.33 (0.76 - 2.35) | 0.32 |
7 | C A C C C C A G A G | 0.0251 | 0.0205 | 0.0327 | 1.74 (0.75 - 4.00) | 0.19 |
8 | C A C C C C G G A G | 0.0202 | 0.0196 | 0.0212 | 1.54 (0.59 - 4.02) | 0.38 |
9 | C A T C C C G G G G | 0.0165 | 0.0177 | 0.0139 | 1.59 (0.56 - 4.48) | 0.38 |
10 | Rare | 0.0703 |