Table 3 Replication of the 5 significant loci in the WOSCOPS trial and CARE study in association with baseline LDL cholesterol levels

From: Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses

			WOSCOPS N = 431			CARE N = 751
SNP	Gene	Chr.	beta	se	p-value	beta	se	p-value
rs445925	APOE APOC1	19	0.07	0.05	0.164	-0.10	0.04	0.006
rs6511720	LDLR	19	-0.03	0.05	0.657	-0.03	0.03	0.411
rs258494*¹	HMGCR	5	0.06	0.03	0.044	0.03	0.02	0.147
rs174541*²	FADS2 FEN1	11	-0.04	0.03	0.264	-0.03	0.02	0.134
rs602633*³	PSRC1 CELSR5	1	-0.09	0.04	0.026	-0.05	0.02	0.035

* A proxy for this SNP was used in both replication cohorts, for ¹ the proxy SNP was rs7715806 with a r² of 0.93, for ² the proxy SNP was rs174545 with a r² of 0.90, and for ³ the proxy SNP was rs660240 with a r² of 0.88.
Abbreviations: SNP, Single Nucleotide Polymorphism; Chr, Chromosome.

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