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Table 3 Replication of the 5 significant loci in the WOSCOPS trial and CARE study in association with baseline LDL cholesterol levels

From: Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses

    WOSCOPS
N = 431
CARE
N = 751
SNP Gene Chr. beta se p-value beta se p-value
rs445925 APOE APOC1 19 0.07 0.05 0.164 -0.10 0.04 0.006
rs6511720 LDLR 19 -0.03 0.05 0.657 -0.03 0.03 0.411
rs258494*1 HMGCR 5 0.06 0.03 0.044 0.03 0.02 0.147
rs174541*2 FADS2
FEN1
11 -0.04 0.03 0.264 -0.03 0.02 0.134
rs602633*3 PSRC1
CELSR5
1 -0.09 0.04 0.026 -0.05 0.02 0.035
  1. * A proxy for this SNP was used in both replication cohorts, for 1 the proxy SNP was rs7715806 with a r2 of 0.93, for 2 the proxy SNP was rs174545 with a r2 of 0.90, and for 3 the proxy SNP was rs660240 with a r2 of 0.88.
  2. Abbreviations: SNP, Single Nucleotide Polymorphism; Chr, Chromosome.