Table 2 Genomic loci with a genome wide significant p-value < = 5
From: Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses
Chr. | Gene | Number of SNPs | TopSNP | Variant | MAF | Beta | SE | p-value | Ref* |
|---|---|---|---|---|---|---|---|---|---|
19 | APOE APOC1 | 17 | rs445925 | G > A | 0.11 | -0.33 | 0.03 | 2.8e-30 | (7;11-14;18;19)] |
19 | LDLR | 5 | rs6511720 | G > T | 0.13 | -0.19 | 0.02 | 5.2e-15 | (7;11;13;14;19)] |
5 | HMGCR | 5 | rs258494 | G > C | 0.38 | 0.10 | 0.02 | 1.3e-09 | (7;11;13;14;19)] |
11 | FADS2 FEN1 | 14 | rs174541 | C > T | 0.38 | -0.10 | 0.02 | 1.1e-08 | (7;11;13;19)] |
1 | PSRC1 CELSR5 | 1 | rs602633 | G > T | 0.23 | -0.11 | 0.02 | 5.0e-08 | (7;11-14;16-19)] |