Skip to main content

Table 2 Genomic loci with a genome wide significant p-value < = 5

From: Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses

Chr. Gene Number of SNPs TopSNP Variant MAF Beta SE p-value Ref*
19 APOE
APOC1
17 rs445925 G > A 0.11 -0.33 0.03 2.8e-30 (7;11-14;18;19)]
19 LDLR 5 rs6511720 G > T 0.13 -0.19 0.02 5.2e-15 (7;11;13;14;19)]
5 HMGCR 5 rs258494 G > C 0.38 0.10 0.02 1.3e-09 (7;11;13;14;19)]
11 FADS2
FEN1
14 rs174541 C > T 0.38 -0.10 0.02 1.1e-08 (7;11;13;19)]
1 PSRC1
CELSR5
1 rs602633 G > T 0.23 -0.11 0.02 5.0e-08 (7;11-14;16-19)]
  1. Abbreviations: SNP, Single Nucleotide Polymorphism; Chr, Chromosome; MAF, minor allele frequency; SE, standard error. * A list of references in which the same loci were found.