From: Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses
 | PROSPER study (n = 5804) | PROSPER/PHASE study (n = 5244) |
---|---|---|
Continuous variables (mean, SD) | Â | Â |
   Age (years) | 75.3 (3.3) | 75.3 (3.4) |
   Education (years) | 15.1 (2.0) | 15.1 (2.0) |
   Systolic blood pressure (mmHg) | 154.7 (21.8) | 154.6 (21.9) |
   Diastolic blood pressure (mmHg) | 83.8 (11.5) | 83.7 (11.4) |
   Height (cm) | 165.2 (9.4) | 165.2 (9.4) |
   Weight (kg) | 73.4 (13.4) | 73.3 (13.4) |
   Body mass index (kg/m2) | 26.8 (4.2) | 26.8 (4.2) |
   Total cholesterol (mmol/L) | 5.7 (0.9) | 5.7 (0.9) |
   LDL cholesterol (mmol/L) | 3.8 (0.8) | 3.8 (0.8) |
   HDL cholesterol (mmol/L) | 1.3 (0.3) | 1.3 (0.4) |
   Triglycerides (mmol/L) | 1.5 (0.7) | 1.5 (0.7) |
Categorical variables (n, %) | Â | Â |
   Males | 2804 (48.3) | 2524 (48.1) |
   Current smoker | 1558 (26.8) | 1392 (26.5) |
   History of diabetes | 623 (10.7) | 544 (10.4) |
   History of hypertension | 3592 (61.9) | 3257 (62.1) |
   History of angina | 1559 (26.9) | 1424 (27.2) |
   History of claudication | 390 (6.7) | 354 (6.8) |
   History of myocardial infarction | 776 (13.4) | 708 (13.5) |
   History of stroke or TIA | 649 (11.2) | 586 (11.2) |
   History of vascular disease* | 2565 (44.2) | 2336 (44.5) |