Table 3 Characteristics of type 1 diabetes patients according to the genotypes of CYBA -675 T → A (unregistered) or GCLC rs17883901 SNPs.
CYBA TT (n = 353) | CYBA TA+AA (n = 48) | Pvalue | GCLC CC (n = 331) | GCLC CT+TT (n = 70) | pvalue | |
|---|---|---|---|---|---|---|
Sex (male/female) (%) | 45/55 | 43/57 | 0.4334 | 53/47 | 38/62 | 0.1259 |
Age (years) | 34.6 (27.7-43) | 33 (27.8-43) | 0.4778 | 35 (27.9-44) | 34.6 (27.1-42) | 0.6965 |
Age at diabetes diagnosis (years) | 12 (7-19) | 13 (10-19) | 0.3466 | 13 (7.5-20) | 11 (7-15.2) | 0.0073 |
Duration of diabetes (years) | 21 (16.4-26) | 20.3 (16-27) | 0.7917 | 21 (16.6-26) | 21.6 (17-29.4) | 0.6799 |
Arterial hypertension (%) | 45.6 | 44.9 | 0.5250 | 46.1 | 43.4 | 0.3937 |
Use of lipid-lowering drugs (%) | 19 | 15.7 | 0.3583 | 17.4 | 25.3 | 0.1336 |
Use of ACE inhibitors (%) | 21.1 | 18.3 | 0.4068 | 18.8 | 31.4 | 0.0164 |
HbA1C (%) | 8.4 (7.4-9.6) | 8.25 (7.2-10) | 0.6329 | 8.3 (7.3-9.8) | 8.3 (7.3-9.3) | 0.9669 |
Cholesterol (mg/dL) | 173 (150-200) | 180 (149.5-209) | 0.4319 | 174 (149-201) | 174 (157-197) | 0.7560 |
HDL cholesterol (mg/dL) | 55 (46-67) | 58 (47-69) | 0.2954 | 57 (47-68) | 52 (43-64.5) | 0.0986 |
LDL cholesterol (mg/dL) | 95 (78-118) | 97 (75.2-124.4) | 0.7686 | 94.4 (78-119) | 94.2 (78-116) | 0.8902 |
Triglycerides (mg/dL) | 82 (58-118) | 73 (54-113) | 0.4712 | 80 (57-119.2) | 85.5 (58-114.2) | 0.3683 |
Overt DN (%) | 36.2 | 20 | 0.0398 | 33.6 | 40 | 0.2387 |
GFR < 60 mL/min (%) | 35.3 | 18.7 | 0.0143 | 31.1 | 47.1 | 0.0082 |