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Table 1 Summary of SNP associations (based on multivariate p-value of < 5 × 10-8)

From: Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits

Chr BP SNP Closest Gene Minor/Major Allele MAF N multivariate P-value Associated Trait(s) Univariate analysis
          N β* SE univariate p
1 109,619,361 rs660240 CELSR2 T/C 0.215 4883 7.0 × 10-9 LDL 11247 -0.170 0.017 2.1 × 10 -22
         HDL 11545 0.047 0.017 0.007
         INS 2559 0.035 0.040 0.390
2 21,097,505 rs10199768 APOB T/G 0.470 4872 2.3 × 10-8 LDL 11205 0.110 0.014 7.7 × 10 -15
         CRP 8878 -0.015 0.015 0.330
         FERR 11285 0.032 0.014 0.020
3 166,973,974 rs1803274 BCHE T/C 0.206 4883 2.4 × 10-42 BCHE 9171 -0.365 0.018 5.9 × 10 -92
4 9,665,474 rs7671266 WDR1 T/C 0.208 4883 1.8 × 10-42 UA 11346 -0.305 0.017 9.3 × 10 -71
4 9,940,392 rs4698036 Intergenic G/T 0.218 4884 8.5 × 10-31 UA 11354 -0.257 0.017 2.3 × 10 -52
8 19,894,037 rs17091905 LPL A/G 0.124 4884 2.8 × 10-13 HDL 11546 0.150 0.022 5.7 × 10 -12
         TRIG 11576 -0.174 0.022 5.1 × 10 -15
         CRP 8918 0.062 0.024 0.008
         BCHE 9168 -0.042 0.032 0.069
10 17,931,828 rs2437258 MRC1 T/C 0.226 4884 7.1 × 10-9 AST 11516 0.102 0.016 3.0 × 10 -10
         FERR 11332 0.015 0.016 0.350
         TRIG 11579 0.027 0.017 0.116
         ALT 11518 -0.012 0.017 0.460
12 119,955,720 rs3213545 OASL A/G 0.295 4876 3.9 × 10-14 GGT 11493 -0.121 0.015 3.6 × 10 -15
         LDL 11228 0.066 0.016 2.9 × 10-5
         CRP 8903 -0.066 0.017 8.8 × 10-5
         TRIG 11556 0.021 0.016 0.180
15 56,465,804 rs10468017 LIPC T/C 0.326 4864 2.8 × 10-11 HDL 11497 0.104 0.015 2.8 × 10 -12
         TRIG 11527 0.048 0.015 0.002
16 55,545,545 rs173539 CETP T/C 0.324 4884 1.7 × 10-40 HDL 11549 0.255 0.015 3.3 × 10 -65
         LDL 11251 -0.050 0.015 0.001
19 50,087,459 rs2075650 TOMM40 G/A 0.152 4884 5.7 × 10-10 LDL 11248 0.153 0.020 1.6 × 10 -14
         CRP 8918 -0.116 0.021 4.2 × 10 -8
         HDL 11546 -0.105 0.020 8.1 × 10-8
         TRIG 11576 0.098 0.020 9.6 × 10-7
  1. SNPs highlighted in bold indicate the polymorphisms that are significantly associated with more than one trait; traits highlighted in bold are those which achieved significance in the univariate analysis.
  2. * β represents 1 unit change in e.g. LDL (mmol/l) per copy increment in the minor allele; TRIG indicates triglycerides.