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Table 3 S-COMT methylation [% ± SD] with respect to COMT genotype in Blood DNA (blood donors)

From: Association of COMT genotypes with S-COMT promoter methylation in growth-discordant monozygotic twins and healthy adults

Variant

CG1

CG2b

mean

CG1

CG2b

mean

CG1

CG2b

mean

p-value

rs6269

AA 47.0 ± 4.6

60.1 ± 3.7

53.6 ± 3.5 (n = 26)

AG 42.2 ± 4.7

55.7 ± 5.1

49.0 ± 4.8 (n = 44)

GG 36.6 ± 4.6

51.4 ± 5.3

44.0 ± 4.8 (n = 23)

< 0.01

rs4680

AA 47.3 ± 4.2

60.3 ± 3.7

53.8 ± 3.4 (n = 33)

AG 40.8 ± 3.8

54.7 ± 4.5

47.8 ± 4.0 (n = 46)

GG 34.1 ± 4.1

49.1 ± 5.4

41.6 ± 4.5 (n = 14)

< 0.01

  1. Note that due to the high linkage disequilibrium between rs6269, rs4633, and rs4680, in the replication cohort we assessed only rs6269 and rs4680, which are sufficient to differentiate between the 3 common activity haplotypes.
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BMC Medical Genetics

ISSN: 1471-2350

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