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Table 2 Association of ACE, NOD1, TLR4, FAS and FASL gene polymorphisms with gastric cancer and high risk atrophic gastritis

From: Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians

Genotypes

Controls (n = 238)

GC (n = 114)

HRAG (n = 222)

 

n (%)

n (%)

OR (95% CI)

p

n (%)

OR (95% CI)

p

ACE I/D

       

I/I

62 (26.1)

27 (23.7)

0.88 (0.52-1.48)

0.632

62 (27.9)

1.10 (0.73-1.66)

0.650

I/D

110 (46.2)

59 (51.8)

1.25 (0.79-1.95)

0.331

108 (48.6)

1.10 (0.76-1.59)

0.602

D/D

66 (27.7)

28 (24.6)

0.85 (0.51-1.42)

0.529

52 (23.4)

0.79 (0.52-1.21)

0.290

Allele I

234 (49.2)

113 (49.6)

1.02 (0.74-1.39)

0.921

232 (52.3)

1.13 (0.87-1.47)

0.348

Allele D

242 (50.8)

115 (50.4)

0.98 (0.72-1.35)

0.921

212 (47.7)

0.88 (0.68-1.15)

0.348

NOD1 796G>A

       

G/G

129 (54.4)

61 (54.5)

1.00 (0.64-1.57)

0.995

138 (62.4)

1.39 (0.96-2.02)

0.082

G/A

85 (35.9)

40 (35.7)

0.99 (0.62-1.59)

1.000

66 (29.9)

0.76 (0.52-1.13)

0.172

A/A

23 (9.7)

11 (9.8)

1.01 (0.48-2.16)

0.973

17 (7.7)

0.78 (0.40-1.49)

0.446

Allele G

343 (72.4)

162 (72.3)

0.99 (0.70-1.42)

0.991

342 (77.4)

1.31 (0.97-1.76)

0.081

Allele A

131 (27.6)

62 (27.7)

1.00 (0.70-1.73)

0.991

100 (22.6)

0.77 (0.57-1.03)

0.081

TLR4 3725G>C

       

G/G

190 (80.5)

90 (79.6)

0.95 (0.54-1.66)

0.849

181 (82.3)

1.12 (0.70-1.80)

0.629

G/C

41 (17.4)

21 (18.6)

1.09 (0.61-1.94)

0.782

33 (15.0)

0.84 (0.51-1.38)

0.492

C/C

5 (2.1)

2 (1.8)

0.83 (0.16-4.36)

0.832

6 (2.7)

1.29 (0.39-4.31)

0.672

Allele G

421 (89.2)

201 (88.9)

0.97 (0.59-1.62)

0.919

395 (89.8)

1.06 (0.69-1.62)

0.776

Allele C

51 (10.8)

25 (11.1)

1.03 (0.62-1.71)

0.919

45 (10.2)

0.94 (0.62-1.44)

0.776

FAS 1377G>A

       

G/G

197 (82.8)

95 (83.3)

1.04 (0.57-1.88)

0.895

178 (80.2)

0.84 (0.52-1.35)

0.471

G/A

40 (16.8)

18 (15.8)

0.92 (0.51-1.70)

0.809

41 (18.5)

1.12 (0.69-1.81)

0.640

A/A

1 (0.4)

1 (0.9)

2.09 (0.13-33.8)

0.593

3 (1.4)

3.2 (0.33-31.4)

0.282

Allele G

434 (91.2)

208 (91.2)

1.00 (0.57-1.75)

0.981

397 (89.4)

0.82 (0.52-1.27)

0.366

Allele A

42 (8.8)

20 (8.8)

0.99 (0.56-1.73)

0.981

47 (10.6)

1.22 (0.79-1.90)

0.366

FAS 670A>G

       

A/A

70 (29.4)

31 (27.2)

0.89 (0.54-1.47)

0.666

68 (30.6)

1.06 (0.71-1.57)

0.775

A/G

127 (53.4)

62 (54.4)

1.04 (0.66-1.63)

0.856

101 (45.5)

0.72 (0.51-1.05)

0.091

G/G

41 (17.2)

21 (18.4)

1.08 (0.60-1.94)

0.783

53 (23.9)

1.50 (0.95-2.39)

0.077

Allele A

267 (56.1)

124 (54.4)

0.93 (0.68-1.28)

0.699

237 (53.4)

0.89 (0.69-1.16)

0.408

Allele G

209 (43.9)

104 (45.6)

1.07 (0.78-1.47)

0.699

207 (46.6)

1.12 (0.86-1.44)

0.408

FASL 844T>C

       

T/T

124 (52.1)

55 (48.2)

0.86 (0.55-1.34)

0.498

108 (48.6)

0.87 (0.60-1.25)

0.459

T/C

94 (39.5)

52 (45.6)

1.28 (0.81-2.01)

0.275

91 (41.0)

1.06 (0.73-1.54)

0.743

C/C

20 (8.4)

7 (6.1)

0.71 (0.29-1.73)

0.455

23 (10.4)

1.26 (0.67-2.36)

0.471

Allele T

342 (71.8)

162 (71.1)

0.96 (0.67-1.36)

0.826

307 (69.1)

0.87 (0.66-1.17)

0.368

Allele C

134 (28.2)

66 (28.9)

1.04 (0.73-1.47)

0.826

137 (30.9)

1.14 (0.86-1.51)

0.368

  1. GC, gastric cancer; HRAG, high risk atrophic gastritis, CI, confidence interval; OR, odds ratio The ORs were calculated comparing each genotype vs. the other two genotypes, the first line for each gene polymorphism represents the dominant model and third line represents the recessive model.