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Table 1 Meta-analysis of FVII gene polymorphisms and CHD

From: Association between polymorphisms in the coagulation factor VII gene and coronary heart disease risk in different ethnicities: a meta-analysis

Polymorphisms Populations Number of studies Number of cases Number of controls MAF % OR(95%CI) P -value I2 %
R353Q European 20 5720 10641 14.2 1.02(0.94-1.11) 0.623 11.4
(rs6046) East Asian 12 2652 2654 8.8 0.70(0.55-0.90) 0.005 55.5
  Other 4 779 804 32.6 0.92(0.78-1.07) 0.280 0.0
  Total 36 9151 14099 12.8 0.91(0.83-1.01) 0.069 51.2
-323Ins10 European 5 926 2426 13.0 0.74(0.61-0.88) 0.001 35.1
(rs36208070) East Asian 5 1620 1476 13.6 0.63(0.53-0.74) < 0.001 0.0
  Other 2 316 338 35.8 1.10(0.84-1.43) 0.500 0.0
  Total 12 2862 4240 17.3 0.73(0.66-0.82) < 0.001 45.2
HVR4 European 4 611 560 32.8 0.82(0.55-1.21) 0.317 76.6
  East Asian 6 1793 1711 42.3 0.87(0.75-1.01) 0.059 47.0
  Other 2 459 456 30.1 0.97(0.68-1.38) 0.844 65.6
  Total 12 2863 2727 38.3 0.88(0.78-1.00) 0.059 57.4
  1. MAF = Minor Allele Frequency (in control groups); OR = Odds Ratio; CI = Confidence Interval;
  2. I2: The inconsistency index for between-studies heterogeneity, where higher values of the index (I2 > 50%) indicate the existence of heterogeneity.