Association between polymorphisms in the coagulation factor VII gene and coronary heart disease risk in different ethnicities: a meta-analysis

Table 1 Meta-analysis of FVII gene polymorphisms and CHD

Polymorphisms	Populations	Number of studies	Number of cases	Number of controls	MAF %	OR(95%CI)	P -value	I² %
R353Q	European	20	5720	10641	14.2	1.02(0.94-1.11)	0.623	11.4
(rs6046)	East Asian	12	2652	2654	8.8	0.70(0.55-0.90)	0.005	55.5
	Other	4	779	804	32.6	0.92(0.78-1.07)	0.280	0.0
	Total	36	9151	14099	12.8	0.91(0.83-1.01)	0.069	51.2
-323Ins10	European	5	926	2426	13.0	0.74(0.61-0.88)	0.001	35.1
(rs36208070)	East Asian	5	1620	1476	13.6	0.63(0.53-0.74)	< 0.001	0.0
	Other	2	316	338	35.8	1.10(0.84-1.43)	0.500	0.0
	Total	12	2862	4240	17.3	0.73(0.66-0.82)	< 0.001	45.2
HVR4	European	4	611	560	32.8	0.82(0.55-1.21)	0.317	76.6
	East Asian	6	1793	1711	42.3	0.87(0.75-1.01)	0.059	47.0
	Other	2	459	456	30.1	0.97(0.68-1.38)	0.844	65.6
	Total	12	2863	2727	38.3	0.88(0.78-1.00)	0.059	57.4

MAF = Minor Allele Frequency (in control groups); OR = Odds Ratio; CI = Confidence Interval;
I²: The inconsistency index for between-studies heterogeneity, where higher values of the index (I² > 50%) indicate the existence of heterogeneity.

ISSN: 1471-2350