Genome-Wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population

Table 2 Top Candidate SNPs from the Ashkenazi Jewish, NINDS and CIDR/Pankratz et al 2009 Datasets

					Ashkenazi Jewish			NINDS			CIDR/Pankratz et al 2009			Meta-analysis
SNP	CHR	BP	A1	GENE	F_A	P	OR	F_A	P	OR	F_A	P	OR	A2	Z	P	Direction
					F_U		95% CI	F_U		95% CI	F_U		95% CI		score
rs1694037	3	21941114	T	LOC10055836	0.096	1.02 × 10^-5	0.42	0.097	0.849	1.02	0.121	0.049	1.24	T	-1.3	0.193	- ++
					0.199		0.29-0.62	0.095		0.81-1.28	0.100		1.00-1.54
rs4976493	5	135210022	A	SLC25A48	0.442	6.66 × 10^-5	1.77	0.403	0.026	1.17	0.367	0.190	0.91	A	2.8	0.005	++-
					0.309		1.34-2.35	0.366		1.02-1.34	0.389		0.79-1.05
rs10121009	9	35259819	A	UNC13B	0.131	5.32 × 10^-5	0.49	0.182	0.045	0.84	0.185	0.032	0.83	A	-4.7	2.75 × 10^-6	- - -
					0.235		0.34-0.69	0.209		0.71-1.00	0.214		0.70-0.98
rs4745122*	9	73582507	A	Intergenic	0.351	5.48 × 10^-5	1.87	0.243	0.007	1.25	0.234	0.748	0.97	A	3.7	2.15 × 10^-4	++-
					0.225		1.38-2.54	0.205		1.06-1.47	0.239		0.83-1.14
rs7171137	15	90363631	A	SLCO3A1	0.397	3.79 × 10^-5	1.84	0.370	0.013	1.20	0.351	0.620	1.04	A	4.1	4.09 × 10^-5	+++
					0.264		1.38-2.47	0.330		1.04-1.38	0.343		0.90-1.19
rs183211	17	42143493	T	NSF	0.207	7.16 × 10^-5	0.54	0.213	0.102	0.87	0.196	0.001	0.77	T	-5.1	2.80 × 10^-7	- - -
					0.326		0.40-0.73	0.236		0.75-1.03	0.241		0.65-0.90
rs415430	17	42214305	C	WNT3	0.202	8.45 × 10^-5	0.54	0.173	0.002	0.77				C	-5.0	6.87 × 10^-7	--
--					0.317		0.40-0.74	0.214		0.65-0.91

A1: Minor allele, A2: Associated allele, F_A: Minor allele freq. of case, F_U: Minor allele freq. of control, OR: odds ratios, 95% CI: 95% confidence interval, * rs4745122 is located ~8.9Kb proximal to TMEM2.

ISSN: 1471-2350