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Table 2 Top Candidate SNPs from the Ashkenazi Jewish, NINDS and CIDR/Pankratz et al 2009 Datasets

From: Genome-Wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population

      Ashkenazi Jewish NINDS CIDR/Pankratz et al 2009 Meta-analysis
SNP CHR BP A1 GENE F_A P OR F_A P OR F_A P OR A2 Z P Direction
      F_U   95% CI F_U   95% CI F_U   95% CI   score   
rs1694037 3 21941114 T LOC10055836 0.096 1.02 × 10-5 0.42 0.097 0.849 1.02 0.121 0.049 1.24 T -1.3 0.193 - ++
      0.199   0.29-0.62 0.095   0.81-1.28 0.100   1.00-1.54     
rs4976493 5 135210022 A SLC25A48 0.442 6.66 × 10-5 1.77 0.403 0.026 1.17 0.367 0.190 0.91 A 2.8 0.005 ++-
      0.309   1.34-2.35 0.366   1.02-1.34 0.389   0.79-1.05     
rs10121009 9 35259819 A UNC13B 0.131 5.32 × 10-5 0.49 0.182 0.045 0.84 0.185 0.032 0.83 A -4.7 2.75 × 10-6 - - -
      0.235   0.34-0.69 0.209   0.71-1.00 0.214   0.70-0.98     
rs4745122* 9 73582507 A Intergenic 0.351 5.48 × 10-5 1.87 0.243 0.007 1.25 0.234 0.748 0.97 A 3.7 2.15 × 10-4 ++-
      0.225   1.38-2.54 0.205   1.06-1.47 0.239   0.83-1.14     
rs7171137 15 90363631 A SLCO3A1 0.397 3.79 × 10-5 1.84 0.370 0.013 1.20 0.351 0.620 1.04 A 4.1 4.09 × 10-5 +++
      0.264   1.38-2.47 0.330   1.04-1.38 0.343   0.90-1.19     
rs183211 17 42143493 T NSF 0.207 7.16 × 10-5 0.54 0.213 0.102 0.87 0.196 0.001 0.77 T -5.1 2.80 × 10-7 - - -
      0.326   0.40-0.73 0.236   0.75-1.03 0.241   0.65-0.90     
rs415430 17 42214305 C WNT3 0.202 8.45 × 10-5 0.54 0.173 0.002 0.77     C -5.0 6.87 × 10-7 --
--      0.317   0.40-0.74 0.214   0.65-0.91        
  1. A1: Minor allele, A2: Associated allele, F_A: Minor allele freq. of case, F_U: Minor allele freq. of control, OR: odds ratios, 95% CI: 95% confidence interval, * rs4745122 is located ~8.9Kb proximal to TMEM2.