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Table 6 In Silico Association With Venous Thrombosis of the Identified vWF- and FVIII Associated SNPs

From: Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels

  

Alleles*

Minor Allele Frequency

Cochran Armitage P-value

   

Cases

Controls

 

vWF associated SNPs

    

VPS8

rs4686760

A/G

0.441

0.475

P = 0.101

EPB41L4A

rs13361927

G/A

0.065

0.062

P = 0.797

KRT18P24

rs1634352†

G/A

0.284

0.318

P = 0.055

12q21.33

rs1438933

G/A

0.256

0.294

P = 0.051

CDH2

rs2298574

A/G

0.084

0.093

P = 0.444

SAFB2

rs732505

G/A

0.061

0.064

P = 0.713

FVIII associated SNPs

    

VAV2

rs12344583

A/G

0.217

0.193

P = 0.133

ACCN1

rs1354492

G/A

0.476

0.469

P = 0.740

ACCN1

rs12941510

G/A

0.310

0.350

P = 0.046

  1. *Common/minor alleles
  2. † serves as proxy for rs1757948 (r2 = 1).
  3. No good proxy with r2 > 0.80 was available for rs6708166 (LBH), rs1321761 (FAM46A) and rs7306642 (STAB2)
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BMC Medical Genetics

ISSN: 1471-2350

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