Table 5 Association of Previously Identified SNPs with FVIII Activity in the three GWAS Datasets
From: Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels
Gene | SNP | Alleles* | MAF+ | β (SE) | p | I2 | phet | Random Effect | Fixed Effect | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β (SE) | p | β (SE) | p | |||||||||
FVL | 0.43 | 0.15 (0.08) | 0.083 | |||||||||
STXBP5 | rs9390459 | G/A | Martha08 | 0.42 | -0.08 (0.06) | 0.158 | 0.65 | 0.059 | -0.02 (0.06) | 0.795 | -0.04 (0.03) | 0.310 |
Martha10 | 0.43 | -0.07 (0.05) | 0.199 | |||||||||
FVL | 0.24 | -0.08 (0.1) | 0.433 | |||||||||
SCARA5 | rs9644133 | C/T | Martha08 | 0.17 | -0.16 (0.07) | 0.029 | 0 | 0.753 | -0.12 (0.05) | 0.009 | -0.12 (0.05) | 0.009 |
Martha10 | 0.18 | -0.10 (0.07) | 0.152 | |||||||||
FVL | 0.45 | 0.11 (0.08) | 0.170 | |||||||||
VWF | rs1063856 | A/G | Martha08 | 0.37 | 0.09 (0.06) | 0.114 | 0 | 0.843 | 0.08 (0.03) | 0.020 | 0.08 (0.03) | 0.020 |
Martha10 | 0.38 | 0.06 (0.05) | 0.249 | |||||||||
FVL | 0.27 | -0.13 (0.09) | 0.146 | |||||||||
STAB2 | rs4981021(1) | G/A | Martha08 | 0.32 | -0.02 (0.06) | 0.737 | 0 | 0.389 | -0.02 (0.04) | 0.521 | -0.02 (0.04) | 0.521 |
Martha10 | 0.29 | 0.02 (0.06) | 0.782 | |||||||||
FVL | 0.14 | -0.03 (0.11) | 0.816 | |||||||||
rs2228671 | C/T | Martha08 | 0.11 | 0.11 (0.09) | 0.193 | 0.46 | 0.157 | -0.01 (0.07) | 0.890 | -0.01 (0.05) | 0.894 | |
LDLR | Martha10 | 0.10 | -0.13 (0.09) | 0.161 | ||||||||
FVL | 0.38 | -0.25 (0.09) | 0.005 | |||||||||
rs688 | C/T | Martha08 | 0.45 | 0.06 (0.05) | 0.235 | 0.79 | 0.010 | -0.05 (0.08) | 0.531 | -0.02 (0.03) | 0.652 | |
Martha10 | 0.45 | -0.007 (0.05) | 0.901 | |||||||||