Table 4 Association of Previously Identified SNPs with vWF Levels in the three GWAS Datasets
From: Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels
Gene | SNP | Alleles* | MAF+ | β (SE) | p | I2 | phet | Random Effect | Fixed Effect | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β (SE) | p | β (SE) | p | |||||||||
FVL | 0.42 | 0.04 (0.08) | 0.618 | |||||||||
BAI3 | rs9363864 | A/G | Martha08 | 0.52 | 0.03 (0.04) | 0.421 | 0 | 0.838 | 0.02 (0.03) | 0.461 | 0.02 (0.03) | 0.461 |
Martha10 | 0.49 | -0.002 (0.05) | 0.973 | |||||||||
FVL | 0.43 | -0.08 (0.08) | 0.366 | |||||||||
STXBP5 | rs9390459 | G/A | Martha08 | 0.42 | -0.06 (0.04) | 0.197 | 0 | 0.545 | -0.09 (0.03) | 0.005 | -0.09 (0.03) | 0.005 |
Martha10 | 0.43 | -0.13 (0.05) | 0.011 | |||||||||
FVL | 0.20 | -0.08 (0.10) | 0.446 | |||||||||
SCARA5 | rs10866867(1) | G/T | Martha08 | 0.25 | 0.17 (0.05) | 4.88e-04 | 0.71 | 0.03 | 0.05 (0.07) | 0.466 | 0.09 (0.04) | 0.015 |
Martha10 | 0.25 | 0.01 (0.06) | 0.830 | |||||||||
FVL | 0.06 | -0.28 (0.19) | 0.141 | |||||||||
rs216335(2) | G/A | Martha08 | 0.08 | -0.23 (0.08) | 0.003 | 0 | 0.945 | -0.23 (0.06) | 1.31 10-4 | -0.23 (0.06) | 1.30 10-4 | |
Martha10 | 0.06 | -0.21 (0.11) | 0.059 | |||||||||
FVL | 0.45 | 0.07 (0.08) | 0.371 | |||||||||
VWF | rs1063856(3) | A/G | Martha08 | 0.37 | 0.08 (0.05) | 0.094 | 0 | 0.889 | 0.09 (0.03) | 0.006 | 0.09 (0.03) | 0.006 |
Martha10 | 0.38 | 0.11 (0.05) | 0.041 | |||||||||
FVL | 0.48 | -0.04 (0.08) | 0.612 | |||||||||
rs7306706 | A/G | Martha08 | 0.45 | 0.02 (0.04) | 0.634 | 0 | 0.754 | 0.01 (0.03) | 0.664 | 0.01 (0.03) | 0.664 | |
Martha10 | 0.46 | 0.03 (0.05) | 0.604 | |||||||||
FVL | 0.30 | -0.05 (0.09) | 0.601 | |||||||||
STAB2 | rs4981022 | T/C | Martha08 | 0.30 | 0.02 (0.05) | 0.652 | 0 | 0.541 | -0.01 (0.03) | 0.664 | -0.01 (0.03) | 0.664 |
Martha10 | 0.28 | -0.06 (0.06) | 0.333 | |||||||||
FVL | 0.33 | 0.01 (0.09) | 0.863 | |||||||||
STX2 | rs4334059(4) | C/T | Martha08 | 0.37 | 0.08 (0.04) | 0.067 | 0.01 | 0.363 | 0.1 (0.03) | 0.004 | 0.1 (0.03) | 0.003 |
Martha10 | 0.36 | 0.15 (0.06) | 0.008 | |||||||||
FVL | 0.52 | 0.05 (0.08) | 0.548 | |||||||||
TC2N | rs2402074(5) | G/A | Martha08 | 0.48 | 0.04 (0.04) | 0.382 | 0 | 0.509 | 0.07 (0.03) | 0.033 | 0.07 (0.03) | 0.033 |
Martha10 | 0.47 | 0.12 (0.05) | 0.030 | |||||||||
FVL | 0.22 | -0.07 (0.1) | 0.515 | |||||||||
CLEC4M | rs868875 | A/G | Martha08 | 0.32 | -0.10 (0.05) | 0.036 | 0 | 0.762 | -0.08 (0.03) | 0.026 | -0.08 (0.03) | 0.026 |
Martha10 | 0.35 | -0.05 (0.06) | 0.424 | |||||||||