Table 2 Ten SNPs Showing Association with vWF levels Across the Three GWAS Datasets With Combined Significance P-value < 10-5
From: Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels
Gene | SNP | Alleles* | MAF+ | β (SE) | p | I2 | phet | Random Effect | Fixed Effect | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β (SE) | p | β (SE) | p | |||||||||
FVL | 0.47 | -0.16 (0.08) | 0.044 | |||||||||
VPS8 | rs4686760 | A/G | Martha08 | 0.46 | -0.18 (0.04) | 4.11 10-5 | 0 | 0.549 | 0.15 (0.03) | 1.10 10-6 | -0.15 (0.03) | 1.08 10-6 |
Martha10 | 0.45 | -0.11 (0.05) | 0.047 | |||||||||
FVL | 0.15 | 0.44 (0.11) | 3.08 10-4 | |||||||||
rs13361927 | G/A | Martha08 | 0.06 | 0.28 (0.09) | 0.003 | 0.53 | 0.119 | -0.28 (0.09) | 0.002 | 0.28 (0.06) | 4.51 10-6 | |
EPB41L4A | Martha10 | 0.05 | 0.11 (0.11) | 0.316 | ||||||||
FVL | 0.12 | 0.46 (0.12) | 8.35 10-4 | |||||||||
rs379440 | A/G | Martha08 | 0.04 | 0.31 (0.11) | 0.004 | 0 | 0.502 | -0.34 (0.07) | 9.99 10-7 | 0.34 (0.07) | 9.82 10-7 | |
Martha10 | 0.03 | 0.25 (0.14) | 0.071 | |||||||||
FVL | 0.04 | -0.01 (0.21) | 0.977 | |||||||||
ANKRD6 | rs6454764 | C/T | Martha08 | 0.06 | 0.24 (0.09) | 0.007 | 0.70 | 0.036 | -0.29 (0.14) | 0.035 | 0.31 (0.07) | 5.12 10-6 |
Martha10 | 0.05 | 0.54 (0.12) | 8.97 10-6 | |||||||||
FVL | 0.27 | 0.34 (0.09) | 2.82 10-4 | |||||||||
KRT18P24 | rs1757948 | T/G | Martha08 | 0.27 | 0.1 (0.05) | 0.030 | 0.62 | 0.071 | -0.18 (0.06) | 0.003 | 0.15 (0.03) | 7.37 10-6 |
Martha10 | 0.30 | 0.15 (0.06) | 0.009 | |||||||||
FVL | 0.19 | 0.15 (0.1) | 0.127 | |||||||||
rs1438993 | G/A | Martha08 | 0.28 | 0.18 (0.05) | 1.11 10-4 | 0 | 0.666 | -0.16 (0.03) | 6.34 10-6 | 0.16 (0.03) | 6.25 10-6 | |
Martha10 | 0.27 | 0.12 (0.06) | 0.052 | |||||||||
FVL | 0.20 | 0.19 (0.1) | 0.062 | |||||||||
desert | rs10745527 | T/G | Martha08 | 0.28 | 0.18 (0.05) | 1.63 10-4 | 0 | 0.663 | -0.16 (0.03) | 5.51 10-6 | 0.16 (0.03) | 5.43 10-6 |
Martha10 | 0.27 | 0.11 (0.06) | 0.056 | |||||||||
FVL | 0.18 | 0.17 (0.11) | 0.098 | |||||||||
rs2579103 | T/G | Martha08 | 0.26 | 0.19 (0.05) | 8.24 10-5 | 0 | 0.533 | -0.16 (0.04) | 7.72 10-6 | 0.16 (0.04) | 7.61 10-6 | |
Martha10 | 0.25 | 0.1 (0.06) | 0.090 | |||||||||
FVL | 0.04 | -0.02 (0.19) | 0.905 | |||||||||
CDH2 | rs2298574 | A/G | Martha08 | 0.08 | -0.34 (0.08) | 2.77 10-5 | 0.19 | 0.290 | 0.26 (0.07) | 1.81 10-4 | -0.27 (0.06) | 5.67 10-6 |
Martha10 | 0.07 | -0.24 (0.1) | 0.022 | |||||||||
FVL | 0.05 | 0.32 (0.18) | 0.080 | |||||||||
SAFB2 | rs732505 | G/A | Martha08 | 0.09 | 0.24 (0.08) | 0.001 | 0 | 0.929 | -0.25 (0.06) | 9.50 10-6 | 0.25 (0.06) | 9.38 10-6 |
Martha10 | 0.08 | 0.25 (0.1) | 0.013 | |||||||||