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Table 1 Summary statistics of cohorts and results of association between Gly482Ser genotypes and BMI.

From: Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1Ais associated with BMI in Tongans

       

Co-dominant

Dominant

Recessive

Population

sample size

male

female

mean age*

mean_BMI* (kg/m2)

risk allele frequency

effect estimate (kg/m2)#

P

effect estimate (kg/m2)#

P

effect estimate (kg/m2)#

P

Maori

110

32

78

48.1 ± 17.7

32.1 ± 7.6

0.833

0.024 ± 1.41

0.99

0.146 ± 1.60

0.93

-0.907 ± 4.52

0.84

Tongans

184

63

121

46.3 ± 14.0

34.0 ± 6.3

0.592

1.397 ± 0.66

0.037

2.341 ± 0.95

0.014

0.940 ± 1.26

0.46

All

294

95

199

47.0 ± 15.5

33.3 ± 6.9

0.686

0.351 ± 0.60

0.56

0.735 ± 0.81

0.366

-0.248 ± 1.29

0.85

  1. * Standard deviation is shown.
  2. # Standard error is shown.
  3. The linear regression model used to produce effect estimates included age and sex as covariates. In the analysis including all populations, "population" was also included as a covariate. Results for all three modes of inheritance (co-dominant, dominant and recessive) are shown. Statistically significant P values (P < 0.05) are shown in bold.