Association of IL1A and IL1B loci with primary open angle glaucoma

BMC Medical Genetics

Table 1 Allele frequencies of SNPs in IL-1 gene cluster in POAG patients and controls

SNP (Gene)	Allele	Patient Subgroup	Patient (n)	Control (n)	p-value	Adjusted p-Value*	OR (95% CI)
-889C/T rs1800587 (IL-1A)		POAG	0.71 (448)		0.204	-	-
	C	Non-HTG	0.74 (296)	0.68 (408)	0.025	0.075	1.380(1.041-1.830)
		HTG	0.66 (152)		0.534	-	-
		POAG	0.29 (182)		0.204	-	-
	T	Non-HTG	0.26 (102)	0.32 (194)	0.025	0.075	0.725(0.547-0.961)
		HTG	0.34 (80)		0.534	-	-
-511C/T rs16944 (IL-1B)		POAG	0.44 (276)		0.114	-	-
	C	Non-HTG	0.43 (173)	0.39(237)	0.197	-	-
		HTG	0.44 (103)		0.185	-	-
		POAG	0.56 (354)		0.114	-	-
	T	Non-HTG	0.57 (225)	0.61(365)	0.197	-	-
		HTG	0.56 (129)		0.185	-	-
+3953C/T rs1143634 (IL-1B)		POAG	0.85 (538)		0.102	-	-
	C	Non-HTG	0.87 (345)	0.89 (533)	0.380	-	-
		HTG	0.83 (193)		0.039	0.117	0.641(0.419-0.979)
		POAG	0.15 (92)		0.102	-
	T	Non-HTG	0.13 (53)	0.11(69)	0.380	-	-
		HTG	0.17 (39)		0.039	0.117	1.561(1.022-2.385)

* P-values were adjusted by Bonferroni method.
The location of the SNP in the genomic region and corresponding dbSNP reference ID is furnished. None of the 3 SNPs was significantly associated with the entire POAG patient cohort or when it is subdivided to two groups: HTG (IOP > 21 mmHg) and non-HTG (IOP < 20 mmHg). The numbers in parenthesis next to 'Allele frequency' represent numbers of chromosomes in the group. The weak association of IL1A (-889C/T) and IL1B (+3953C/T) polymorphisms were nullified after Bonferroni adjustments for multiple tests.

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