Skip to main content

Table 3 Association between type 2 diabetes and 19 SNPs in the eight genes/loci

From: Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population

Gene

SNP

No.

LDa D'(r2)

P value for HWEb

Allel Frequency

Additive model

    

Cases

Controls

Cases

Controls

Trend p value

Adjusted p value

ORc (95% CI)d

Adjusted p value

OR (95% CI)

Adjusted p value

OR (95% CI)

TCF7L2

rs6585205 (T)

1

1 vs 2: 0.28 (0.0070)

0.54

0.31

0.43

0.39

0.003

0.055

 

4.0 × 10-4

1.31 (1.13, 1.53)

0.287

1.11 (0.92, 1.35)

 

rs7903146 (T)

2

1 vs 3: 0.72 (0.33)

0.25

0.24

0.06

0.04

3.6 × 10-4

0.007

1.54 (1.19, 1.99)

0.001

1.58 (1.25, 2.03)

0.691

1.41 (0.40, 5.02)

 

rs11196218 (A)

3

2 vs 3: 0.28 (0.01)

0.26

0.60

0.29

0.30

0.520

9.880

     

HHEX

rs1111875 (G)

4

5 vs 4: 0.39 (0.11)

0.11

0.32

0.32

0.28

0.001

0.016

1.11 (0.97, 1.27)

0.005

1.23 (1.07, 1.42)

0.011

1.43 (1.08, 1.89)

 

rs7923837 (G)

5

5 vs 6: 0.53 (0.18)

0.24

0.99

0.30

0.25

1.4 × 10-5

2.7 × 10-4

1.08 (0.93, 1.25)

8.6 × 10-6

1.39 (1.20, 1.61)

0.062

1.30 (0.99, 1.72)

 

rs5015480 (C)

6

4 vs 6: 0.69 (0.21)

0.69

0.41

0.21

0.17

0.001

0.027

1.20 (0.96, 1.54)

3.3 × 10-4

1.32 (1.14, 1.54)

0.657

1.08 (0.75, 1.59)

CDKLA1

rs736425 (C)

7

8 vs 9: 0.55 (0.056)

0.48

0.93

0.07

0.07

0.782

14.849

     
 

rs10946398 (C)

8

7 vs 8: 0.11 (0.0011)

0.79

0.36

0.45

0.37

1.2 × 10-9

2.2 × 10-8

1.36 (1.20, 1.55)

2.7 × 10-6

1.44 (1.24, 1.68)

6.3 × 10-9

1.78 (1.46, 2.17)

 

rs4712527 (G)

9

7 vs 9: 0.086 (0.0020)

0.07

0.52

0.22

0.21

0.270

5.132

     

SCL30A8

rs13266634 (C)

10

10 vs 11 0.99 (0.55)

0.13

0.08

0.59

0.54

1.4 × 10-4

0.003

1.37 (1.20, 1.56)

0.005

1.32 (1.09, 1.60)

0.001

1.31 (1.11, 1.53)

 

rs3802177 (C)

11

10 vs 12 0.95 (0.64)

0.96

0.15

0.60

0.53

9.9 × 10-8

1.9 × 10-6

1.33 (1.18, 1.52)

0.007

1.29 (1.07, 1.57)

1.2 × 10-8

1.58 (1.35, 1.84)

 

rs11558471 (A)

12

11 vs 12 0.96 (0.67)

0.96

0.86

0.58

0.52

3.5 × 10-6

6.6 × 10-5

1.25 (1.11, 1.41)

1.7 × 10-4

1.41 (1.18, 1.69)

1.5 × 10-4

1.35 (1.16, 1.59)

PPARG

rs180282 (G)

13

13 vs 14: 0.87 (0.079)

0.30

0.78

0.06

0.05

0.394

7.482

     
 

rs12636454 (C)

14

14 vs 15: 0.89 (0.38)

0.95

0.81

0.32

0.33

0.523

9.928

     
 

rs11128597 (A)

15

13 vs 15: 0.70 (0.022)

0.14

0.43

0.48

0.46

0.296

5.618

     

IGF2BP2

rs4402960 (T)

16

 

0.46

0.53

0.23

0.22

0.176

3.335

     

KCNJ11

rs5215 (C)

17

 

0.21

0.28

0.42

0.41

0.225

4.277

     

CDKN2A/

rs564398 (C)

18

18 vs 19 0.12 (0.0011)

0.00

0.27

0.01

0.01

0.627

11.913

     

CDKN2B

rs10811661 (C)

19

 

0.26

0.56

0.05

0.05

0.880

1.670

     
  1. a: Linkage disequilibrium (LD), b: Hardy-Weinberg equilibrium, c: Odds ratio (OR), d: Confidence interval (CI).