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Table 3 Allele frequencies and genotype frequencies of the SNPs of the ACE gene and the eNOS gene in cases and controls

From: Association of the genetic polymorphisms of the ACE gene and the eNOSgene with lupus nephropathy in northern Chinese population

SNP

Genotype

Control N = 232 (%)

Lupus nephropathy N = 225 (%)

p

OR (95%CI)

 

AA

79(34.05)

108(48.44)

0.002*

0.559(0.384-0.816)

 

AC

107(46.12)

91(40.44)

0.221

1.260(0.870-1.826)

ACEA-5466C

CC

46(19.83)

26(11.56)

0.015*

1.893(1.124-3.186)

 

A allele

265(57.11%)

307(68.22%)

0.001*

0.620(0.473-0.813)

 

C allele

199(42.89%)

143(31.78%)

0.001*

1.612(1.230-2.113)

 

TT

50(21.55)

43(19.11)

0.517

1.163(0.737-1.835)

 

TC

112(48.28)

99(44.00)

0.359

1.188(0.822-1.717)

ACE T-3892C

CC

70(30.17)

83(36.89)

0.128

0.739(0.501-1.092)

 

T allele

212(45.69%)

185(41.11%)

0.163

1.205(0.927-1.566)

 

C allele

252(54.31%)

265(58.89%)

0.163

0.830(0.639-1.078)

 

AA

93(40.09)

79(35.11)

0.272

1.236(0.846-1.807)

 

AT

102(43.97)

111(47.84)

0.250

0.806(0.558-1.164)

ACEA-240T

TT

37(15.95)

35(15.56)

0.908

1.030(0.623-1.704)

 

A allele

273 (62.07%)

269(59.78%)

0.772

0.962(0.739-1.252)

 

T allele

191(37.93%)

181(40.22%)

0.772

1.040(0.799-1.354)

ACE C1237T

CC

24(10.34)

19(8.44)

0.487

1.251(0.665-2.353)

 

CT

89(38.36)

96(42.67)

0.349

0.836(0.575-1.216)

 

TT

119(51.29)

110(48.89)

0.607

1.101(0.763-1.589)

 

C allele

137(29.53%)

134(29.78%)

0.934

0.988(0.744-1.312)

 

T allele

327(70.47%)

316(70.22%)

0.934

1.012(0.762-1.344)

 

GG

98(42.24)

87(38.67)

0.436

1.160(0.798-1.686)

 

AG

102(43.97)

102(45.33)

0.769

0.946(0.654-1.368)

ACEG2215A

AA

32(13.79)

36(16.00)

0.507

0.840(0.501-1.407)

 

G allele

298(64.22%)

276(61.33%)

0.366

1.132(0.865-1.480)

 

A allele

166(35.78%)

174(38.67%)

0.366

0.884(0.676-1.156)

 

AA

138(59.48)

163(72.44)

0.003*

0.558(0.377-0.827)

 

AG

75(32.33)

53(23.56)

0.037*

1.550(1.026-2.343)

ACEA2350G

GG

19 (8.19)

9(4.00)

0.062

2.141(0.947-4.838)

 

A allele

351(75.65%)

379(84.22%)

0.001*

0.582(0.418-0.810)

 

G allele

113(24.35%)

71(15.78%)

0.001*

1.719(1.235-2.391)

 

CC

9(3.88)

11(4.89)

0.598

0.785(0.319-1.933)

 

TC

59(25.43)

57(25.33)

0.981

1.005(0.660-1.532)

eNOS T-786C

TT

164(70.69)

157(69.78)

0.831

1.045(0.699-1.560)

 

T allele

387(83.41%)

371(82.44%)

0.700

1.070(0.758-1.511)

 

C allele

77(16.59%)

79(17.56%)

0.700

0.934(0.662-1.319)

eNOS G894T

GG

179(77.16)

195(86.67)

0.008*

0.520(0.318-0.850)

 

GT

46(19.83)

27(12.00)

0.022*

1.814(1.083-3.037)

 

TT

7(3.02)

3(1.33)

0.215

2.312(0.593-9.019)

 

G allele

404(87.07%)

417(92.67%)

0.005*

0.533(0.341-0.833)

 

T allele

60(12.93%)

33(7.33%)

0.005*

1.877(1.201-2.932)

  1. * p < 0.05
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