From: Sex-differential genetic effect of phosphodiesterase 4D (PDE4D) on carotid atherosclerosis
Atherosclerotic risk | Overall | Men | Women | ||||||
---|---|---|---|---|---|---|---|---|---|
 | AA + AT | TT | statistics | AA + AT | TT | statistics | AA + AT | TT | statistics |
Carotid plaque | N = 544 | N = 108 | Â | N = 216 | N = 40 | Â | N = 328 | N = 68 | Â |
   No plaque (index = 0) | 354 (83.7%) | 69 (16.3%) | ref. | 129 (86.6%) | 20 (13.4%) | ref. | 225 (82.1%) | 49 (17.9%) | ref. |
   Low-risk (index = 1-3) | 163 (84.5%) | 30 (15.5%) | OR = 1.0 (0.6-1.7) p = 0.934 | 66 (84.6%) | 12 (15.4%) | OR = 1.5 (0.7-3.6) p = 0.312 | 97 (84.3%) | 18 (15.7%) | OR = 0.8 (0.4-1.5) P = 0.534 |
   High-risk (index ≥ 4) | 27 (75.0%) | 9 (25.0%) | OR = 3.1 (1.1-8.7) p = 0.034 | 21 (72.4%) | 8 (27.6%) | OR = 5.9 (1.6-21.5) p = 0.008 | 6 (85.7%) | 1 (14.3%) | OR = NA |
Age-adjusted IMT(mm) | N = 775 | N = 162 | Â | N = 367 | N = 76 | Â | N = 408 | N = 86 | Â |
   CCA | 0.61 ± 0.12 | 0.62 ± 0.11 | p = 0.150 | 0.63 ± 0.14 | 0.66 ± 0.13 | p = 0.041 | 0.59 ± 0.10 | 0.59 ± 0.08 | p = 0.862 |
   Bif | 0.65 ± 0.12 | 0.66 ± 0.13 | p = 0. 396 | 0.67 ± 0.12 | 0.70 ± 0.14 | p = 0.068 | 0.63 ± 0.11 | 0.62 ± 0.09 | p = 0.472 |
   ICA | 0.51 ± 0.10 | 0.51 ± 0.11 | p = 0.518 | 0.53 ± 0.11 | 0.55 ± 0.13 | p = 0.111 | 0.48 ± 0.08 | 0.48 ± 0.08 | p = 0.441 |
Dichotomized IMT (advanced atherosclerotic group(> mean + 1SD) | |||||||||
   CCA | 98 (12.7%) | 23 (14.5%), | OR = 1.2 (0.7-1.9) p = 0.584 | 43 (11.7%) | 17(22.4%) | OR = 2.1 (1.1-4.1) p = 0.032 | 55 (13.5%) | 6 (7.2%) | OR = 0.5 (0.2-1.2) p = 0.109 |
   Bif | 110 (14.2%) | 30 (18.9%), | OR = 1.5 (0.9-2.3) p = 0.099 | 53 (14.5%) | 17 (22.4%) | OR = 1.8 (0.9-3.3) p = 0.078 | 57 (14.0%) | 13 (15.7%) | OR = 1.1 (0.6-2.2) p = 0.686 |
   ICA | 96 (12.5%) | 20 (12.7%), | OR = 1.0 (0.6-1.7) p = 0.940 | 36 (9.9%) | 7 (9.2%) | OR = 0.8 (0.3-1.9) p = 0.588 | 60 (14.8%) | 13 (16.0%) | OR = 1.1 (0.6-2.2) p = 0.724 |