Table 3 Distribution of genotypes of the studied CTLA4 polymorphisms1
Variants | Genotype frequency cases n = 333, controls n = 482 | Dominant model2 | Log-additive model2 | ||
|---|---|---|---|---|---|
rs736611 | T/T | T/C | C/C | Genotype T/C + C/C | Allele C |
CD | 37% | 48% | 15% | 63% | 39% |
Controls | 34% | 48% | 18% | 66% | 42% |
OR (95%CI) | Â | Â | Â | 0.89 (0.67 - 1.19) | 0.86 (0.70 - 1.05) |
g.49A > G (rs231775) | A/A | A/G | G/G | Genotype A/G + G/G | Allele G |
CD | 41% | 46% | 13% | 59% | 36% |
Controls | 40% | 44% | 16% | 61% | 38% |
OR (95%CI) | Â | Â | Â | 0.85 (0.63 - 1.14) | 0.89 (0.72 - 1.09) |
CT60 (rs3087243) | G/G | G/A | A/A | Genotype G/A + A/A | Allele A |
CD | 33% | 48% | 19% | 68% | 43% |
Controls | 35% | 48% | 17% | 65% | 41% |
OR (95%CI) | Â | Â | Â | 1.11 (0.82 - 1.50) | 1.10 (0.90 - 1.35) |
JO31 (rs11571302) | G/G | G/T | T/T | Genotype G/T + T/T | Allele T |
CD | 29% | 50% | 21% | 71% | 46% |
Controls | 31% | 49% | 20% | 69% | 44% |
OR (95%CI) | Â | Â | Â | 1.12 (0.82 - 1.53) | 1.09 (0.89 - 1.34) |
JO27-1 (rs11571297) | A/A | A/G | G/G | Genotype A/G + G/G | Allele G |
CD | 29% | 49% | 22% | 72% | 47% |
Controls | 30% | 50% | 20% | 70% | 45% |
OR (95%CI) | Â | Â | Â | 1.12 (0.82 - 1.53) | 1.11 (0.91 - 1.36) |