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Table 2 Relative risk estimates for REN (A) and AGT (B) haplotypes

From: Maternal angiotensinogen (AGT) haplotypes, fetal renin (REN) haplotypes and risk of preeclampsia; estimation of gene-gene interaction from family-triad data

A: Relative risk estimates (95% CI; p-value) for maternal AGThaplotypes (n = 87 family triads)
AGThaplotype Frequency (%) Single dose Double dose
C-T-A 58.3 0.39 (0.18-0.84); 0.02 0.60 (0.24-1.51); 0.28
C-c-g 20.9 1.42 (0.65-3.12); 0.38 3.00 (0.93-9.93); 0.07
t-c-g 20.4 1.46 (0.66-3.20); 0.35 4.63 (1.46-14.7); 0.01
B: Relative risk estimates (95% CI; p-value) for fetal REN haplotypes (n = 90 family triads)
REN haplotype Frequency (%) Single dose Double dose
A-G-C 59.5 0.63 (0.27-1.46); 0.27 0.36 (0.13-0.98); 0.05
A-t-C 31.6 0.86 (0.37-1.95); 0.72 0.40 (0.12-1.39); 0.15
c-G-t 8.5 1.45 (0.66-3.19); 0.35 Not estimable
  1. SNP order for AGT: rs218582 (C/t), rs2478545 (c/T) and rs943580 (A/g)
  2. SNP order for REN: rs5705 (A/c), rs1464816 (G/t) and rs3795575 (C/t)