No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes

Table 2 Associations of NR4A1 SNPs rs2701124 and rs1283155 with metabolic parameters (n = 1495).

SNP	rs2701124					rs1283155
Genotype	CC	CT	TT	P_add.	P_dom.	CC	CT	TT	P_add.	P_dom.
N	1242	239	8	-	-	885	507	83	-	-
BMI (kg/m²)	28.5 ± 7.8	29.0 ± 8.6	32.3 ± 16.1	0.5	0.3	28.7 ± 8.2	28.5 ± 7.7	28.3 ± 7.7	0.8	0.6
Waist circumference (cm)	94 ± 17	93 ± 19	93 ± 28	1.0	0.8	94 ± 18	94 ± 17	93 ± 16	0.9	0.8
Glucose, fasting (mM)	5.10 ± 0.55	5.06 ± 0.54	5.11 ± 0.64	0.6	0.3	5.10 ± 0.55	5.10 ± 0.56	5.04 ± 0.48	0.4	0.7
Glucose, 120 min. OGTT (mM)	6.25 ± 1.66	6.22 ± 1.64	5.94 ± 1.75	0.7	0.7	6.32 ± 1.67	6.07 ± 1.62	6.46 ± 1.66	0.0078	0.0153
HOMA-IR (U)	2.41 ± 2.11	2.47 ± 2.35	2.68 ± 1.82	0.5	0.2	2.51 ± 2.30	2.31 ± 1.87	2.25 ± 2.28	0.3	0.17
ISI, OGTT (U)	16.6 ± 10.9	16.7 ± 10.5	16.1 ± 13.2	0.7	0.4	16.3 ± 10.7	16.9 ± 10.9	17.1 ± 10.9	0.2	0.08
ISI, clamp (U)^#	0.086 ± 0.054	0.087 ± 0.058	0.054 ± 0.001	0.8	0.5	0.084 ± 0.052	0.089 ± 0.061	0.090 ± 0.046	0.7	0.9
AUC Insulin [30 min.]/AUC glc [30 min.] (pM/mM)	40.2 ± 29.0	41.4 ± 35.5	44.9 ± 23.8	0.9	0.6	41.3 ± 30.8	39.7 ± 28.4	37.8 ± 34.0	0.7	0.8
AUC C-pep/AUC glc (pM/mM)	317 ± 106	329 ± 113	312 ± 72	0.2	0.10	320 ± 103	320 ± 113	304 ± 108	0.6	0.9
Insulinogenic index (pM/mM)	50.3 ± 39.4	52.1 ± 48.4	56.1 ± 32.8	0.9	0.7	51.5 ± 41.7	50.0 ± 39.3	46.7 ± 44.6	0.8	0.6

Raw data are presented and given as means ± SD. For statistical analysis, data were log_e-transformed. AUC Insulin [30 min.]/AUC glc [30 min.], AUC C-pep/AUC glc, and insulinogenic index were adjusted for gender, age, BMI, and ISI-OGTT. Fasting glucose, glucose at 120 min. of the OGTT, HOMA-IR, ISI-OGTT, and ISI-clamp were adjusted for gender, age, and BMI. BMI and waist circumference were adjusted for gender and age. AUC - area under the curve; BMI - body mass index; C-pep - C-peptide; glc - glucose; HOMA-IR - homeostasis model assessment of insulin resistance; ISI - insulin sensitivity index; OGTT - oral glucose tolerance test; p_add. - p-value in the addidtive inheritance model; p_dom. - p-value in the dominant inheritance model; SNP - single nucleotide polymorphism; U - units. ^# ISI (clamp) data were available from 506 subjects.
Insulinogenic index was assessed as the ratio of (insulin at 30 min. of the OGTT - fasting insulin) to glucose at 30 min. of the OGTT.

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