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Table 1 Associations of NR4A1 SNPs rs744690, rs2603751, and rs2242107 with metabolic parameters (n = 1495).

From: No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes

SNP

rs744690

  

rs2603751

  

rs2242107

  

Genotype

TT

TG

GG

Padd.

Pdom.

AA

AG

GG

Padd.

Pdom.

CC

CT

TT

Padd.

Pdom.

N

1066

384

39

-

-

1156

313

20

-

-

769

589

131

-

-

BMI (kg/m2)

28.4 ± 8.1

28.4 ± 7.5

28.3 ± 7.4

0.8

0.6

28.5 ± 7.9

28.8 ± 8.2

29.6 ± 11.1

0.8

0.5

28.6 ± 7.9

28.4 ± 7.9

29.2 ± 8.8

0.7

0.9

Waist circumference (cm)

93 ± 17

94 ± 17

92 ± 15

0.7

0.9

94 ± 17

94 ± 18

91 ± 20

0.9

0.9

94 ± 17

93 ± 17

95 ± 18

0.4

0.4

Glucose, fasting (mM)

5.09 ± 0.55

5.10 ± 0.55

5.15 ± 0.54

0.8

0.5

5.10 ± 0.55

5.07 ± 0.54

4.96 ± 0.53

0.3

0.2

5.11 ± 0.56

5.07 ± 0.54

5.12 ± 0.53

0.7

0.4

Glucose, 120 min. OGTT (mM)

6.28 ± 1.65

6.11 ± 1.67

6.47 ± 1.73

0.14

0.08

6.24 ± 1.67

6.25 ± 1.63

6.09 ± 1.46

0.9

1.0

6.29 ± 1.68

6.17 ± 1.62

6.25 ± 1.68

0.4

0.15

HOMA-IR (U)

2.44 ± 2.11

2.36 ± 2.20

2.47 ± 2.73

0.8

1.0

2.42 ± 2.16

2.40 ± 2.12

2.78 ± 2.33

0.5

0.4

2.49 ± 2.13

2.28 ± 2.07

2.65 ± 2.57

0.06

0.06

ISI, OGTT (U)

16.7 ± 11.1

16.6 ± 10.3

15.4 ± 7.7

0.9

0.7

16.6 ± 10.9

16.6 ± 10.7

15.4 ± 11.1

0.7

0.7

16.4 ± 11.0

17.1 ± 10.8

15.7 ± 9.8

0.13

0.08

ISI, clamp (U)#

0.086 ± 0.053

0.086 ± 0.061

0.081 ± 0.040

0.9

0.6

0.086 ± 0.054

0.088 ± 0.058

0.046 ± 0.013

0.3

0.4

0.086 ± 0.054

0.085 ± 0.054

0.085 ± 0.064

0.7

0.8

AUC Ins [30 min.]/AUC glc [30 min.] (pM/mM)

40.5 ± 29.7

40.8 ± 32.0

35.2 ± 18.2

0.6

0.5

40.4 ± 29.1

40.0 ± 33.4

47.5 ± 29.4

0.2

0.3

41.0 ± 30.2

38.8 ± 27.5

44.1 ± 39.0

0.8

0.9

AUC C-pep/AUC glc (pM/mM)

317 ± 104

324 ± 117

304 ± 82

0.7

0.5

317 ± 106

324 ± 111

325 ± 111

0.6

0.3

318 ± 105

317 ± 106

331 ± 121

0.5

0.4

Insulinogenic index (pM/mM)

50.5 ± 40.5

51.8 ± 43.5

42.2 ± 22.8

0.7

0.4

50.6 ± 39.7

49.9 ± 45.4

58.6 ± 36.0

0.4

0.5

51.2 ± 41.4

48.7 ± 37.1

55.7 ± 52.6

0.6

0.8

  1. Raw data are presented and given as means ± SD. For statistical analysis, data were log e -transformed. AUC Insulin [30 min.]/AUC glc [30 min.], AUC C-pep/AUC glc, and insulinogenic index were adjusted for gender, age, BMI, and ISI-OGTT. Fasting glucose, glucose at 120 min. of the OGTT, HOMA-IR, ISI-OGTT, and ISI-clamp were adjusted for gender, age, and BMI. BMI and waist circumference were adjusted for gender and age. AUC - area under the curve; BMI - body mass index; C-pep - C-peptide; glc - glucose; HOMA-IR - homeostasis model assessment of insulin resistance; ISI - insulin sensitivity index; OGTT - oral glucose tolerance test; p>add. - p-value in the addidtive inheritance model; pdom. - p-value in the dominant inheritance model; SNP - single nucleotide polymorphism; U - units. #N = 506.
  2. Insulinogenic index was assessed as the ratio of (insulin at 30 min. of the OGTT - fasting insulin) to glucose at 30 min. of the OGTT.