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Table 4 The genotype-phenotype relationship in control individuals at CDKAL1 and FTO genetic loci.

From: Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population

SNPs Genotype Male/Female Age (yrs) BMI (kg/m2) Fasting glucose (mmol/l) Fasting insulin (pmol/l) HOMA-ί HOMA-IR
CDKAL1 rs10946398 AA 40/117 57 ± 8 25.1 ± 2.9 5.2 ± 0.4 50.1(34.1-71.7) 81.5(59.2-118.1) 1.6(1.2-2.5)
  AC 65/188 57 ± 8 25.1 ± 3.2 5.3 ± 0.4 46.7(36.9-66.9) 80.5(57.3-109.8) 1.5(1.1-2.3)
  CC 22/56 57 ± 9 25.9 ± 3.6 5.4 ± 0.4 48.1(36.9-64.8) 77.1(57.4-106.3) 1.6(1.2-2.3)
  Dominant p-value - - 0.650 0.140 0.268 0.142 0.268
  Additive p-value - - 0.131 0.161 0.525 0.034(0.019)a 0.155
  Recessive p-value - - 0.053 0.044(0.046)a 0.802 0.043(0.021)a 0.228
FTO rs8050136 CC 108/278 57 ± 8 25.1 ± 3.2 5.3 ± 0.4 45.3(32.7-63.4) 76.6(54.3-106.3) 1.5(1.1-2.2)
  CA/AA 19/85 57 ± 8 25.8 ± 3.2 5.2 ± 0.4 55.7(43.2-75.2) 94.3(73.5-129.6) 1.8(1.4-2.6)
  Dominant p value - - 0.04(0.037)b 0.148 <0.00001(0.005)a 0.004(0.017)a 0.005(0.035)a
  1. Data are the means ± SD, or median(interquartile range). Test models refer to the minor allele. Only the dominant model was considered in which the minor allele homozygote count was ≤10. Bold: P-value < 0.05. Unadjusted p values without parentheses and p values with parentheses adjusted for a (gender, age, and BMI) and b (gender and age).