Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population

Table 4 The genotype-phenotype relationship in control individuals at CDKAL1 and FTO genetic loci.

SNPs	Genotype	Male/Female	Age (yrs)	BMI (kg/m²)	Fasting glucose (mmol/l)	Fasting insulin (pmol/l)	HOMA-ί	HOMA-IR
CDKAL1 rs10946398	AA	40/117	57 ± 8	25.1 ± 2.9	5.2 ± 0.4	50.1(34.1-71.7)	81.5(59.2-118.1)	1.6(1.2-2.5)
	AC	65/188	57 ± 8	25.1 ± 3.2	5.3 ± 0.4	46.7(36.9-66.9)	80.5(57.3-109.8)	1.5(1.1-2.3)
	CC	22/56	57 ± 9	25.9 ± 3.6	5.4 ± 0.4	48.1(36.9-64.8)	77.1(57.4-106.3)	1.6(1.2-2.3)
	Dominant p-value	-	-	0.650	0.140	0.268	0.142	0.268
	Additive p-value	-	-	0.131	0.161	0.525	0.034(0.019)a	0.155
	Recessive p-value	-	-	0.053	0.044(0.046)a	0.802	0.043(0.021)a	0.228
FTO rs8050136	CC	108/278	57 ± 8	25.1 ± 3.2	5.3 ± 0.4	45.3(32.7-63.4)	76.6(54.3-106.3)	1.5(1.1-2.2)
	CA/AA	19/85	57 ± 8	25.8 ± 3.2	5.2 ± 0.4	55.7(43.2-75.2)	94.3(73.5-129.6)	1.8(1.4-2.6)
	Dominant p value	-	-	0.04(0.037)b	0.148	<0.00001(0.005)a	0.004(0.017)a	0.005(0.035)a

Data are the means ± SD, or median(interquartile range). Test models refer to the minor allele. Only the dominant model was considered in which the minor allele homozygote count was ≤10. Bold: P-value < 0.05. Unadjusted p values without parentheses and p values with parentheses adjusted for a (gender, age, and BMI) and b (gender and age).

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