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Table 3 Meta-analysis for SNPs at nine genetic loci in the Chinese Han population living in China.

From: Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population

Chr SNP Gene Risk allele Case risk AF Control risk AF Pfor heterogeneity OR (95%CI) Pfor overall effect References
9 rs10811661 CDKN2A/B T 0.60 0.54 0.07 1.28(1.21-1.36) <0.00001 [1012]
8 rs13266634 SLC30A8 C 0.58 0.52 0.10 1.19(1.13-1.25) <0.00001 [6, 1012, 27]
6 rs10946398 CDKAL1 C 0.45 0.41 0.03 1.24(1.13-1.37) <0.00001 [10, 12, 15]
11 rs 2237892 KCNQ1 C 0.72 0.66 0.01 1.33(1.18-1.49) <0.00001 [2326]
4 rs6446482 WFS1 G 0.96 0.95 0.53 1.26(1.06-1.51) 0.009 [12]
10 rs5015480 HHEX C 0.20 0.16 0.12 1.24(1.12-1.38) <0.00001 [10, 11]
17 rs7501939 TCF2 T 0.28 0.26 0.88 1.16(1.08-1.24) <0.00001 [5, 38]
3 rs4402960 IGF2BP2 T 0.27 0.24 0.22 1.14(1.06-1.22) 0.0002 [10, 11, 15]
16 rs8050136 FTO A 0.14 0.12 0.80 1.17(1.09-1.27) <0.00001 [11, 12, 14, 30]
  1. AF: allele frequency; OR: Odds ratio; CI: confidence interval; All of the calculations for the meta-analysis were carried out on Revman4.2. Cochran's x2-based Q-statistic test was used to assess heterogeneity in all studies, and a random-effect model was adopted when heterogeneity existed, otherwise a fixed-effects model was appropriate. Combined ORs were calculated using the Mantel-Haenszel (fixed-effects) and DerSimonian and Laird (random-effects) tests. The significant P value of the overall ORs was determined using a Z-test.