Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population

Table 3 Meta-analysis for SNPs at nine genetic loci in the Chinese Han population living in China.

Chr	SNP	Gene	Risk allele	Case risk AF	Control risk AF	Pfor heterogeneity	OR (95%CI)	Pfor overall effect	References
9	rs10811661	CDKN2A/B	T	0.60	0.54	0.07	1.28(1.21-1.36)	<0.00001	[10–12]
8	rs13266634	SLC30A8	C	0.58	0.52	0.10	1.19(1.13-1.25)	<0.00001	[6, 10–12, 27]
6	rs10946398	CDKAL1	C	0.45	0.41	0.03	1.24(1.13-1.37)	<0.00001	[10, 12, 15]
11	rs 2237892	KCNQ1	C	0.72	0.66	0.01	1.33(1.18-1.49)	<0.00001	[23–26]
4	rs6446482	WFS1	G	0.96	0.95	0.53	1.26(1.06-1.51)	0.009	[12]
10	rs5015480	HHEX	C	0.20	0.16	0.12	1.24(1.12-1.38)	<0.00001	[10, 11]
17	rs7501939	TCF2	T	0.28	0.26	0.88	1.16(1.08-1.24)	<0.00001	[5, 38]
3	rs4402960	IGF2BP2	T	0.27	0.24	0.22	1.14(1.06-1.22)	0.0002	[10, 11, 15]
16	rs8050136	FTO	A	0.14	0.12	0.80	1.17(1.09-1.27)	<0.00001	[11, 12, 14, 30]

AF: allele frequency; OR: Odds ratio; CI: confidence interval; All of the calculations for the meta-analysis were carried out on Revman4.2. Cochran's x²-based Q-statistic test was used to assess heterogeneity in all studies, and a random-effect model was adopted when heterogeneity existed, otherwise a fixed-effects model was appropriate. Combined ORs were calculated using the Mantel-Haenszel (fixed-effects) and DerSimonian and Laird (random-effects) tests. The significant P value of the overall ORs was determined using a Z-test.

ISSN: 1471-2350