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Table 4 Association of TGCT with blood-derived DNA global (LINE-1) methylation levels.

From: LINE-1 methylation is inherited in familial testicular cancer kindreds

Relative methylation level in tertiles Healthy Males§ TGCT Cases* OR (95% CI) Pvalue
  No. (%) No. (%)   
All patients    
Low (≤78.8) 38 (33.3) 57 (37.8) 1.83 (0.91, 3.66) 0.089
Middle (78.9-80.6) 39 (34.2) 52 (34.4) 1.41 (0.71, 2.80)  
High (>80.6) 37 (32.5) 42 (27.8) 1.00 (ref)  
Patients with seminoma   
Low 38 (33.3) 29 (39.7) 2.21 (0.90, 5.43) 0.085
Middle 39 (34.2) 27 (37.0) 1.76 (0.72, 4.30)  
High 37 (32.5) 17 (23.3) 1.00 (ref)  
Patients with non-seminoma   
Low 38 (33.3) 26 (35.1) 1.56 (0.67, 3.66) 0.306
Middle 39 (34.2) 23 (31.5) 1.18 (0.50, 2.78)  
High 37 (32.5) 25 (33.8) 1.00 (ref)  
Multi-case families     
Low 38 (33.3) 41 (35.3) 1.68 (0.80, 3.49) 0.174
Middle 39 (34.2) 41 (35.3) 1.51 (0.74, 3.10)  
High 37 (32.5) 34 (29.3) 1.00 (ref)  
Bilateral TGCT families    
Low 38 (33.3) 15 (44.1) 2.12 (0.75, 6.01) 0.218
Middle 39 (34.2) 11 (32.4) 1.23 (0.43, 3.46)  
High 37 (32.5) 8 (23.4) 1.00 (ref)  
  1. Odds ratios (95% confidence intervals) adjusted for age and microlithiasis status;
  2. § Males without cancer or other testicular abnormalities;
  3. * Only 151 total TGCT cases, one subject with teratocarcinoma failed bisulfite conversion;
  4. Families with two or more cases of TGCT;
  5. A single family member had bilateral testicular cancer.