From: LINE-1 methylation is inherited in familial testicular cancer kindreds
Relative methylation level in tertiles | Healthy Males§ | TGCT Cases* | OR†(95% CI) | Pvalue |
---|---|---|---|---|
 | No. (%) | No. (%) |  |  |
All patients | Â | Â | Â | |
Low (≤78.8) | 38 (33.3) | 57 (37.8) | 1.83 (0.91, 3.66) | 0.089 |
Middle (78.9-80.6) | 39 (34.2) | 52 (34.4) | 1.41 (0.71, 2.80) | Â |
High (>80.6) | 37 (32.5) | 42 (27.8) | 1.00 (ref) | Â |
Patients with seminoma | Â | Â | ||
Low | 38 (33.3) | 29 (39.7) | 2.21 (0.90, 5.43) | 0.085 |
Middle | 39 (34.2) | 27 (37.0) | 1.76 (0.72, 4.30) | Â |
High | 37 (32.5) | 17 (23.3) | 1.00 (ref) | Â |
Patients with non-seminoma | Â | Â | ||
Low | 38 (33.3) | 26 (35.1) | 1.56 (0.67, 3.66) | 0.306 |
Middle | 39 (34.2) | 23 (31.5) | 1.18 (0.50, 2.78) | Â |
High | 37 (32.5) | 25 (33.8) | 1.00 (ref) | Â |
Multi-case families‡ |  |  |  |  |
Low | 38 (33.3) | 41 (35.3) | 1.68 (0.80, 3.49) | 0.174 |
Middle | 39 (34.2) | 41 (35.3) | 1.51 (0.74, 3.10) | Â |
High | 37 (32.5) | 34 (29.3) | 1.00 (ref) | Â |
Bilateral TGCT families¶ |  |  |  | |
Low | 38 (33.3) | 15 (44.1) | 2.12 (0.75, 6.01) | 0.218 |
Middle | 39 (34.2) | 11 (32.4) | 1.23 (0.43, 3.46) | Â |
High | 37 (32.5) | 8 (23.4) | 1.00 (ref) | Â |