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Table 4 Association of TGCT with blood-derived DNA global (LINE-1) methylation levels.

From: LINE-1 methylation is inherited in familial testicular cancer kindreds

Relative methylation level in tertiles

Healthy Males§

TGCT Cases*

OR† (95% CI)

Pvalue

 

No. (%)

No. (%)

  

All patients

   

Low (≤78.8)

38 (33.3)

57 (37.8)

1.83 (0.91, 3.66)

0.089

Middle (78.9-80.6)

39 (34.2)

52 (34.4)

1.41 (0.71, 2.80)

 

High (>80.6)

37 (32.5)

42 (27.8)

1.00 (ref)

 

Patients with seminoma

  

Low

38 (33.3)

29 (39.7)

2.21 (0.90, 5.43)

0.085

Middle

39 (34.2)

27 (37.0)

1.76 (0.72, 4.30)

 

High

37 (32.5)

17 (23.3)

1.00 (ref)

 

Patients with non-seminoma

  

Low

38 (33.3)

26 (35.1)

1.56 (0.67, 3.66)

0.306

Middle

39 (34.2)

23 (31.5)

1.18 (0.50, 2.78)

 

High

37 (32.5)

25 (33.8)

1.00 (ref)

 

Multi-case families‡

    

Low

38 (33.3)

41 (35.3)

1.68 (0.80, 3.49)

0.174

Middle

39 (34.2)

41 (35.3)

1.51 (0.74, 3.10)

 

High

37 (32.5)

34 (29.3)

1.00 (ref)

 

Bilateral TGCT families¶

   

Low

38 (33.3)

15 (44.1)

2.12 (0.75, 6.01)

0.218

Middle

39 (34.2)

11 (32.4)

1.23 (0.43, 3.46)

 

High

37 (32.5)

8 (23.4)

1.00 (ref)

 
  1. † Odds ratios (95% confidence intervals) adjusted for age and microlithiasis status;
  2. § Males without cancer or other testicular abnormalities;
  3. * Only 151 total TGCT cases, one subject with teratocarcinoma failed bisulfite conversion;
  4. ‡ Families with two or more cases of TGCT;
  5. ¶ A single family member had bilateral testicular cancer.