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Table 1 Global (LINE-1) methylation levels and characteristics of all subjects.

From: LINE-1 methylation is inherited in familial testicular cancer kindreds

Variables No. (%) Mean level* 95% CI P
Family, healthy 255 (54.7) 79.31 79.06-79.56  
Family, other cancer 39 (8.4) 79.11 78.47-79.74  
Family, other condition§ 20 (4.3) 79.71 78.84-80.58  
TGCT patients 152 (32.6) 79.13 78.78-79.45 0.377
   Multi-case families 118 (77.6) 79.50 79.12-79.88  
   Sporadic bilateral TGCT 34 (22.4) 78.91 78.21-79.60 0.142¥
Gender     
   Male 114 (44.7) 79.60 79.26-79.95  
   Female 141 (55.3) 78.87 78.55-79.18 0.002
Patient TGCT type     
   NOS 4 (2.6) 77.74 75.68-79.81  
   Seminoma 73 (48) 79.19 78.70-79.68  
   Non-seminoma 75 (49.3) 79.59 79.11-80.08 0.267a
Choriocarcinoma 2 (2.7) 79.53 76.86-82.20  
Embryonal 15 (20) 79.88 78.90-80.86  
Germinoma 2 (2.7) 78.58 75.91-81.26  
Mixed germ cell 34 (45.3) 79.19 78.52-79.86  
Teratocarcinoma 20 (26.7) 80.78 79.84-81.73  
Yolk sac tumor 2 (2.7) 76.06 74.27-79.85  
Total participants 466 79.25 79.08-79.43  
  1. * Adjusted for age;
  2. § Other testicular conditions (e.g., hernia or cryptorchidism);
  3. Healthy family only;
  4. For methylation level difference between TGCT patients and healthy family, adjusted for age and sex;
  5. ¥ For methylation level difference between patients from multiple case families vs. sporadic bilateral TGCT patients, adjusted for age;
  6. For methylation level difference between males and females, adjusted for age;
  7. a For methylation level difference between TGCT patients with seminoma vs. non-seminoma, adjusted for age;
  8. NOS = not otherwise specified.