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Table 1 Global (LINE-1) methylation levels and characteristics of all subjects.

From: LINE-1 methylation is inherited in familial testicular cancer kindreds

Variables

No. (%)

Mean level*

95% CI

P

Family, healthy

255 (54.7)

79.31

79.06-79.56

 

Family, other cancer

39 (8.4)

79.11

78.47-79.74

 

Family, other condition§

20 (4.3)

79.71

78.84-80.58

 

TGCT patients

152 (32.6)

79.13

78.78-79.45

0.377

   Multi-case families

118 (77.6)

79.50

79.12-79.88

 

   Sporadic bilateral TGCT

34 (22.4)

78.91

78.21-79.60

0.142¥

Gender

    

   Male

114 (44.7)

79.60

79.26-79.95

 

   Female

141 (55.3)

78.87

78.55-79.18

0.002

Patient TGCT type

    

   NOS

4 (2.6)

77.74

75.68-79.81

 

   Seminoma

73 (48)

79.19

78.70-79.68

 

   Non-seminoma

75 (49.3)

79.59

79.11-80.08

0.267a

Choriocarcinoma

2 (2.7)

79.53

76.86-82.20

 

Embryonal

15 (20)

79.88

78.90-80.86

 

Germinoma

2 (2.7)

78.58

75.91-81.26

 

Mixed germ cell

34 (45.3)

79.19

78.52-79.86

 

Teratocarcinoma

20 (26.7)

80.78

79.84-81.73

 

Yolk sac tumor

2 (2.7)

76.06

74.27-79.85

 

Total participants

466

79.25

79.08-79.43

 
  1. * Adjusted for age;
  2. § Other testicular conditions (e.g., hernia or cryptorchidism);
  3. Healthy family only;
  4. For methylation level difference between TGCT patients and healthy family, adjusted for age and sex;
  5. ¥ For methylation level difference between patients from multiple case families vs. sporadic bilateral TGCT patients, adjusted for age;
  6. For methylation level difference between males and females, adjusted for age;
  7. a For methylation level difference between TGCT patients with seminoma vs. non-seminoma, adjusted for age;
  8. NOS = not otherwise specified.