Association of MMP - 12 polymorphisms with severe and very severe COPD: A case control study of MMPs - 1, 9 and 12in a European population

Table 6 MMPs -1, 12 and 9 - Allelic frequencies in Controls and Cases

Gene	SNP No.	Locus	Major/Minor Alleles	Minor Allele Frequencies		Unadjusted P-value	Adjusted P-value*	Adjusted Odds Ratio**
				Controls	COPD all cases
*MMP* 1	1	rs2071230	A/G	0.08	0.07	0.4354	0.7453	1.045
	2	rs2239008	G/A	0.20	0.20	0.6539	0.5193	0.943
	3	rs470215	A/G	0.38	0.36	0.3502	0.5923	1.041
	4	rs1938901	C/T	0.28	0.31	0.1248	0.2060	0.904
	5	rs17881293	A/G	0.06	0.06	0.9887	0.8005	1.039
	6	rs17884110	-/C	0.38	0.36	0.2574	0.5656	1.044
	7	rs17878931	C/A	0.14	0.14	0.5514	0.4245	0.919
	8	rs10488	G/A	0.06	0.06	0.9190	0.7863	1.042
	9	rs470358	C/T	0.34	0.35	0.4928	0.6550	0.966
	10	rs3213460	G/A	0.14	0.15	0.5609	0.2504	0.889
	11	rs514921	A/G	0.29	0.29	0.9823	0.7495	1.026
	12	rs498186	A/C	0.46	0.47	0.4443	0.3265	0.931
	13	rs1799750	-/G	0.48	0.48	0.8539	0.6630	0.969
*MMP* 12	14	rs652438	A/G	0.05	0.05	0.4773	0.6428	1.078
	15	rs632009	C/T	0.33	0.33	0.9704	0.4266	1.063
	16	rs11225442	G/A	0.13	0.13	0.6509	0.6242	1.053
	17	rs28381675	A/G	0.06	0.07	0.3088	0.0910	0.784
	18	rs2276109	A/G	0.13	0.11	0.0659	0.3243	1.115
*MMP* 9	19	rs3918262	A/G	0.19	0.21	0.0591	0.0647	0.846
	20	rs13969	C/A	0.38	0.39	0.5351	0.9600	0.996
	21	rs2250889	C/G	0.04	0.04	0.4558	0.3645	1.185
	22	rs3918256	A/G	0.40	0.41	0.5548	0.9810	1.002
	23	rs17576	A/G	0.34	0.36	0.3622	0.4367	0.943
	24	rs2274755	G/T	0.16	0.14	0.3908	0.4962	1.072
	25	rs3918278	G/A	0.02	0.02	0.6433	0.0371	0.604
	26	rs11697325	A/G	0.38	0.39	0.3478	0.5696	0.959

ISSN: 1471-2350