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Table 5 The comparison of association results for T60N, G-308A and G-238A between the present study and the WTCCC T2D GWAS

From: Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes

SNP

OR allele

ORa

95% CIa

p-value

WTCCC SNPb

ORa

95% CIa

p-value

rs1041981 (T60N)

C

0.89

0.81-0.98

0.02

rs1041981

1.06

0.96-1.16

0.67

rs1800629 (G-308A)

A

0.98

0.88-1.11

0.79

rs1800629

1.05

0.93-1.19

0.56

rs361525 (G-238A)

G

0.98

0.81-1.19

0.85

rs3093668 (proxy for rs361525)

0.86

0.71-1.05

0.21

  1. aOR - allelic odds ratio and 95% confidence intervals; bAll three SNPs were imputed in the WTCCC data set. 58.2% of WTCCC cases and 35.3% of WTCCC controls overlapped with the samples from our study.