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Table 5 Multiple linear regression model for the association between variants and TG levels adjusting for covariates.

From: Additive effects of LPL, APOA5 and APOEvariant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study

Variable

B1

95% confidence interval

pvalue

LPL-protective variant combination2

0.920

0.895 - 0.947

<0.0001

LPL-D9N3

1.142

1.000 - 1.303

0.048

LPL-N291S3

1.198

1.048 - 1.369

<0.01

APOA5-S19W3

1.128

1.054 - 1.206

<0.001

APOA5- (-1131T/C)3

1.154

1.075 - 1.239

<0.0001

APOE-ε23

1.038

0.966 - 1.115

0.309

APOE-ε43

1.109

1.045 - 1.176

<0.001

  1. Statistical analysis was performed excluding one subject with TG > 11.29 mmol/L and those taking lipid lowering drugs (n = 1731). R2 of the model 0.30.
  2. 1Multiplicative coefficient of the effect of each variant, obtained after undoing logarithmic transformation.
  3. 2One protective variant or two protective variants versus reference (no protective variants).
  4. 3Carriers of the minor allele (homozygous and heterozygous) versus reference (homozygous for the frequent allele)
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