Association and interaction of PPAR-complex gene variants with latent traits of left ventricular diastolic function

Table 6 Significant Gene-Gene interactions in three PPAR-complex genes with latent LVDD endophenotype (E61).

Gene	Locus	Gene Context	Main Effect	P Value	Within-Gene Interaction	P value	Gene-Gene Interaction	P Value
PPARGC1A	rs12500214	Intron 2	Y	0.047	Y (rs2970847)	0.0278	N	0.0094
PPARGC1A	rs7672915	Intron 2	N		Y (rs12500214)	0.0092	N
PPARGC1A	rs2970847	Exon 8	Y	0.037	Y (rs768695)	0.0276	N
PPARGC1A	rs768695	Intron 12	N		Y (rs2970853)	0.0262	N	0.0318
PPARGC1A	rs4235308	Intron 2	N		Y (rs7672915)	0.0068	N
PPARGC1A	rs2970870	Promoter	Y	0.025	N		N
PPARG	rs3856806	Exon 7	Y	0.010	N		N
PPARGC1A	rs1873532	Intron 10	N		N		Y (PPARA, rs4253655)	0.0214
PPARGC1A	rs4697046	Intron 2	N		N		Y (PPARG, rs1151996)	0.0163
PPARGC1A	rs7672915	Intron 2	N		N		Y (PPARA, rs4253655)	0.0212

ISSN: 1471-2350